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Home / Cells / Cell Lines

CD38 / BCMA / Firefly Luciferase CHO Recombinant Cell Line

SKU : BHC18200085

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BPS Bioscience

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Mfr.No.	78148
Description	Recombinant clonal stable CHO cell line constitutively expressing full length human CD38 protein (also known as ADPRC1, Genbank accession #NM_001775) and human BCMA protein (B-Cell Maturation Antigen or CD269, GenBank accession #NM_001192). This cell line was derived from our CHO-K1 Luciferase cells (Biohippo, #79725), therefore it also constitutively expresses the firefly luciferase reporter. Surface expression of CD38 and BCMA was confirmed by flow cytometry. Mycoplasma testing: The cell line has been screened using the MycoAlert Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as 2 vials of frozen cells. 2 x 10^6 cells in 1 ml of 10% DMSO
Background	The CD38 protein is a dimeric, non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes the second messengers cyclic ADP-ribose and NADP. CD38 is highly expressed by lymphoid and myeloid cells, particularly plasma cells. Increased CD38 expression on chronic lymphocytic leukemia (CLL) cells is linked to aggressive disease features and poor clinical outcome. CD38 is used as a prognostic marker for patients with CLL and multiple myeloma (MM), and is an ideal target for immunotherapy in CLL and MM. B-Cell Maturation Antigen (BCMA), also known as CD269, is a cell surface receptor of the TNF receptor superfamily that recognizes B-Cell Activating Factor (BAFF). BCMA is preferentially expressed on mature B-lymphocytes and Multiple Myeloma (MM) cells. BCMA is a highly attractive target antigen for immunotherapy, not only because of its restricted expression in nonmalignant tissue, but also due to its almost universal expression on MM cells. Pre-clinical studies using CAR (Chimeric Antigen Receptor) T cells targeting BCMA have demonstrated anti-MM activity, and in 2017, the FDA granted BCMA CAR T-Cell immunotherapy the breakthrough designation in treating Multiple Myeloma.
Application	1. Useful for validation of anti-CD38 and anti-BCMA bispecific antibody. 2. Useful as CD38- and/or BCMA-expressing target cells in co-culture assay with CD38- and/or BCMA-CAR-T cells, for both CD38/BCMA-specific cell killing assay and cytokine production assay.
Host Cell	CHO
Species	Human
Synonyms	cluster of differentiation 38 cells, ADP-Ribosyl Cyclase 1 cell line, NAD(+) Nucleosidase cell line, ADPRC 1 cell line, TNFRSF17 cells, BCM cell line, CD269 cells, TNFRSF13A cell line, B-Cell Maturation Antigen cells
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200085	78148	2 vials	$11374		Add to Cart

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