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Home / Cells / Cell Lines

CD20/Firefly Luciferase CHO Cell Line

SKU : BHC18200164

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BPS Bioscience

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Mfr.No.	78620
Description	Recombinant clonal stable CHO-K1 cell line constitutively expressing both the full length human CD20 protein, also known as MS4A1 (Genbank #NM_152866), and the firefly (Photinus pyralis) luciferase. Surface expression of CD20 was confirmed by flow cytometry. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains>2 x 10⁶ cells in 1 ml of Cell Freezing Medium (Biohippo, #79796)
Background	CD20 (MS4A1) is a glycosylated phosphoprotein expressed on the cell surface of B cells. CD20 is a highly attractive target antigen for immunotherapy because it is highly expressed in more than 90% of patients with B-cell lymphoma. First approved in 1997, Rituximab (Rituxan) is a chimeric monoclonal antibody targeting CD20 and has been classified by the World Health Organization as an "Essential Medicine". Since then, additional monoclonal antibodies against CD20 have been approved or are being tested in clinical trials for the treatment of multiple sclerosis (MS), chronic lymphocytic leukemia (CLL), follicular lymphoma, diffuse large B cell lymphoma (DLBCL), rheumatoid arthritis, non-Hodgkin's lymphoma, systemic lupus erythematosus, and myalgic encephalomyelitis (chronic fatigue syndrome). More recently, anti-CD20-CD19 bispecific CAR-T cells have been developed to address concerns over potential relapse.
Application	Useful for CD20 binding assays to screen for potential CD20 ligands.Useful as CD20-expressing target cells in co-culture assays with Anti-CD20-CAR-T cells.
Host Cell	CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Species	Human
Synonyms	B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD_antigen: CD20, MS4A1
Shipping Temperature	-80°C (dry ice)
Note	Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long-term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200164	78620	2 vials	$10340		Add to Cart

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