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B7-H4 CHO Cell Line-78586-M

SKU : BHC18200280

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BPS Bioscience

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Mfr.No.	78586-M
Description	B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7-H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 [removed]Medium and High), to mimic different B7-H4 expression levels in various cancer types. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo #79796)
Background	B7-H4 is an immune checkpoint that belongs to the B7 family and is encoded by the VTCN1 gene. B7-H4 is expressed on the surface of antigen presenting cells, interacting with currently unidentified ligands to negatively regulate immune cell responses and suppress tumor-associated immunity. B7-H4 also contributes to changes in the tumor microenvironment that benefit cancer cells and support their proliferation, survival, invasion, and metastasis. B7-H4 is highly expressed in some cancer cells, and has been correlated with tumor progression, particularly in ovarian and breast cancer, making it an attractive target for immunotherapy.
Application	Screen and validate antibodies against B7-H4 for drug discovery and research Screen for compounds or ligands that regulate or inhibit B7-H4 signaling in a cellular context Optimize and perform biological assays
Host Cell	CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Uniprot	Q7Z7D3
Species	Human
Synonyms	V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4 (B7-H4), B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1, UNQ659/PRO1291, B7H4
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200280	78586-M	2 vials	$7865		Add to Cart

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