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AP-1 Reporter - HEK293 Cell Line (JNK signaling pathway)

SKU : BHC18200003

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BPS Bioscience

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Mfr.No.	60405
Description	The AP-1 Reporter - HEK293 Cell Linee is designed for monitoring the activity of the JNK signaling pathway. The AP1 Reporter - HEK293 cell line contains a firefly luciferase gene under the control of AP1-responsive elements that are stably integrated into HEK293 cells. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO.
Background	The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins incluces mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. cJun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription.
Application	Monitor the JNK signaling pathway activity and AP1-mediated activity. Screen for activators or inhibitors of the JNK signaling pathway.
Biological Activity	This cell line is validated for its response to stimulation by Phorbol 12-Myristate 13-Acetate (PMA) and to treatment with inhibitors of the JNK signaling pathway.
Host Cell	HEK293
Synonyms	JNK reporter, AP-1 cell line, activator protein-1 cell line
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Aqueous solution containing DMSO
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Zhou H. et al. (2005). 11: 139-150. 2. Gaillard P. et.al. (2005). 48(14):4596-4607.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200003	60405	2 vials	$2689.50		Add to Cart

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