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TLR8/ NF-kappab Reporter - HEK293 Recombinant Cell Line

SKU : BHC18200062

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BPS Bioscience

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Mfr.No.	60684
Description	Recombinant HEK293 cell expressing firefly luciferase gene under the control of NFkappaB response elements with constitutive expression of human TLR8 (Toll-like receptor 8, also known as CD288, a member of the toll-like receptor (TLR) family (GenBank Accession No. NM_138636). Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains 2 x 106 cells in 1 ml of 10% DMSO
Background	The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 is an endosomal receptor that recognizes single stranded RNA (ssRNA), and can recognize ssRNA viruses such as Influenza, HIV and HCV. TLR8 binding to the viral RNA recruits MyD88 and leads to activation of the transcription factor NF-kappaB and an antiviral response. Human TLR8 is functional but murine TLR8 is non-functional because it lacks five amino acids.
Application	Screen for activators or inhibitors of TLR8 signaling in a cellular context Characterize the biological activity of TLR8 and its interactions with ligands
Host Cell	HEK293
Synonyms	CD288, TLR8, Toll-like receptor 8
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Storage Stability	Immediately upon receipt, store vials in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200062	60684	2 vials	$1732.50		Add to Cart

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