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Home / Cells / Cell Lines

TCR Knockout Jurkat Cell Line

SKU : BHC18200151

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BPS Bioscience

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Mfr.No.	78539
Description	The TCR Knockout Jurkat cell line was generated by CRISPR/Cas9 genome editing to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRalpha and beta chains. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo #79796)
Background	The T-Cell Receptor (TCR) is found on the surface of T cells and is responsible for recognizing antigens bound to MHC (Major Histocompatibility Complex) molecules. Engagement of the TCR initiates downstream NFAT signaling resulting in T cell activation. The TCR consists of a heterodimer of two different protein chains, of which the alpha (alpha) and beta (beta) chains are the predominant chains. CRISPR/Cas9 genome editing was utilized to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) regions of the alpha and beta chains, resulting in a loss of TCR expression.
Application	Use as a control when generating or charaterizing CAR-T Cells
Host Cell	Jurkat (clone E6-1), human T lymphoblast, suspension
Shipping Temperature	-80°C (dry ice)
Note	The CRISPR/CAS9 technology is covered under numerous patents, including U.S. Patent Nos. 8,697,359 and 8,771,945, as well as corresponding foreign patents applications, and patent rights.License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200151	78539	2 vials	$7150		Add to Cart

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