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NaV1.7-HEK293 Cell Line

SKU : BHC18200016

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Mfr.No.	60507
Description	Stable recombinant HEK293 cell line expressing human Nav1.7 (Genbank # Q15858) fused atthe C-terminus to Green Fluorescent Protein (Ex. ~395 nm, 475 nm; em ~510 nm) and with CterminalStreptavidin-Binding Peptide (SBP) fusion. Nav1.7 is a tetrodotoxin-sensitive voltagegatedsodium channel type IX subunit alpha (SCN9A). MW: 242 kDa (calc.) Host Species: human Supplied as Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO.
Background	Nav1.7 is a voltage-gated sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types of neurons, the nociceptive neurons at dorsalroot ganglion and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system. Nav1.7 is present at the endings of pain-sensing nerves, the nociceptors, close to the region where the impulse is initiated.The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to the level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed reduced response to inflammatory pain.
Application	Screen for activators or inhibitors of Nav1.7 Functional assays for Nav1.7 Efficient antigen for mouse immunization
Biological Activity	Functionally validated by Western blotting of NaV1.7 using anti-Sodium channel Nav1.7, clone N68/6 (Millipore, #MABN41) and Alkaline Phosphatase conjugated anti-mouse IgG. Also validated for NaV1.7 expression on the cell surface, measured by flow cytometry (FACS) using anti-NaV 1.7 clone 68/6 and PE-labeled anti-mouse IgG.
Host Cell	HEK293
Uniprot	Q15858
Species	Human
Synonyms	Nav1.7, SCN9A, tetrodotoxin-sensitive voltage-gated sodium channel type IX subunit alpha
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Catterall, W.A. Cell and Developmental Biology 16: 521-555 (2000). 2. Choi, J.S., et al. Neurology 67:1563-1567 (2006). 3. Li, Y., el al. Protein Science 20 (1): 140-149 (2011).

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200016	60507	2 vials	$12204.50		Add to Cart

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