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LAG-3 / NFAT Reporter - Jurkat Recombinant Cell Line

SKU : BHC18200070

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BPS Bioscience

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Mfr.No.	71278
Description	Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human LAG-3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286). Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human
Background	Lymphocyte-activation gene 3 (LAG-3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG-3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG-3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG-3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG-3 antibody can both activate effector T cells (by downregulating the LAG-3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
Application	Screen for activators or inhibitors of LAG-3 signaling in a cellular context and characterize the biological activity of LAG-3 and its interactions with ligands
Host Cell	Jurkat
Uniprot	P18627
Species	Human
Synonyms	LAG3, LAG-3, CD223, Cell Line, Jurkat
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200070	71278	2 vials	$12204.50		Add to Cart

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