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IDO1-HEK293 Recombinant Cell line

SKU : BHC18200023

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BPS Bioscience

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Mfr.No.	60532
Description	Stable Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO1) Genbank accession number NM_002164. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~1.5 X 106 cells in 1 ml of 10% DMSO
Background	L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis inmammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a keyregulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains animmunosuppressive microenvironment by starving immune cells of L-Trp and releasingdegradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulatedin many tumors, providing cancer cells with an avenue for immune evasion.
Application	Monitor IDO1 pathway activity. Screen for activators or inhibitors of IDO1 in a cellular context
Host Cell	HEK293
Species	Human
Synonyms	Indoleamine 2,3-dioxygenase 1, IDO
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Aqueous solution containing DMSO
Storage Stability	Immediately upon receipt, store vials in liquid nitrogen.

Reference	1. Yue, E., et al., J. Med. Chem. 2009; 52: 7364-7367. 2. Liu, X., et al., Blood. 2010; 115(17): 3520-3530.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200023	60532	2 vials	$11374		Add to Cart

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