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Human EGFRvIII- CHO K1 Recombinant Cell Line (Low Expression)

SKU : BHC18200249

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BPS Bioscience

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Mfr.No.	78145-L
Description	Recombinant hEGFRvIII-CHO K1 cell line stably expressing full-length human EGFRvIII receptor (accession number NP_001333870). Surface expression of hEGFRvIII was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hEGFRvIII [removed]High and Low) to mimic different stages of cancer target cells with various EGFRvIII expression levels. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as 2 vials of frozen cells. 2 x 10^6 in 1 ml of 90% FBS, 10% DMSO
Background	Background The epidermal growth factor receptor (EGFR, ErbB-1, HER1) belongs to a family of receptor tyrosine kinases that includes three other closely-related members (HER2, HER3 and HER4). EGFR gene amplification, mutation and re-arrangement are frequently observed in primary glioblastoma multiforme (GBM). The most common EGFR variant in GBM, EGFRvIII, is characterized by a deletion of 267 amino acids in the extracellular domain, leading to a receptor that is unable to bind ligand yet is constitutively active. EGFRvIII enhances the tumorigenic potential of GBM by activating and sustaining mitogenic, anti-apoptotic, and pro-invasive signaling pathways.
Application	Screen for inhibitors of EGFRvIII signaling for immuno-oncology research and drug discovery.
Host Cell	CHO-K1
Species	Human
Synonyms	ERBB cells, HER1 cell line, NISBD2 stable cells , PIG61 cells, epidermal growth factor receptor cell line, 78145-L, 78145-H
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200249	78145-L	2 vials	$7865		Add to Cart

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