CHD8 has a role in chromatin dynamic, transcription and cell survival in which it interacts with p53 to regulate cell cycle genes. It has been associated with developmental disorders like ASD (autism spectrum disorders). CHD8+/ iPSC were derived from skin fibroblasts obtained from a typically developing male control who had a normal karyotype, in which a CHD8 allele was knocked out using CRISPR/Cas9 gene editing. The two lines can be utilized by researchers interested in brain development, neurodevelopmental disorders, and cancer.
Categories
Stem Cells
Application
For research use only
Species
Human
Shipping
Dry Ice
Storage
Liquid Nitrogen
Reviews of HighQC CHD8+/ Induced Pluripotent Stem Cell