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Claudin-6 CHO Cell Line (Low Expression)

SKU : BHC18200269

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BPS Bioscience

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Mfr.No.	78527-L
Description	Recombinant clonal CHO cell line stably expressing full-length human claudin-6 (CLDN6 gene accession number NM_021195.5). Surface expression of claudin 6 was confirmed by flow cytometry. The stable clonal cell line was selected for high, medium, or low levels of claudin-6 expression compared to the parental CHO-K1 cell line. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo #79796)
Background	Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-6 is one of the 27 members of the claudin family.Claudin-6 is widely expressed in various tumors but rarely expressed in healthy adult tissues. This cancer specific expression of claudin-6 makes it a promising target as an antigen for cancer immunotherapy. Several therapeutics that target claudin-6 are currently in development or in clinical trials including bispecific antibodies, monoclonal antibodies, and CAR-T cell therapy products.
Application	Screen and validate antibodies against claudin-6 for drug discovery and research.Screen for compounds that regulate or inhibit claudin-6 signaling in a cellular context.Perform binding assays to screen for potential claudin-6 ligands.
Host Cell	CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Uniprot	P56747
Synonyms	Skullin, CLDN6, UNQ757, PRO1488
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected] Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200269	78527-L	2 vials	$7865		Add to Cart

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