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CD33 - CHO K1 Recombinant Cell Line (High Expression)

SKU : BHC18200321

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BPS Bioscience

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Mfr.No.	79935-H
Description	Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 [removed]High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels. Amino acid sequence: Human CD33/Siglec-3 (accession number: BC028152.1) was cloned into pCMV3. Mycoplasma testing: This cell line has been screened using the MycoAlert Mycoplasma Detection Kit (Lonza,#LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Lonza, #LT07-518) was used as a positive control. Host Species: hamster Supplied as Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Background	CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage that belongs to the sialic acid-binding immunoglobulin (Ig)-like family. CD33 can be stimulated by sialic acid residues on glycoproteins or glycolipids, resulting in a signaling cascade that inhibits phagocytosis in cells and suppresses immune cell proliferation. CD33 overexpression is one of top-ranked Alzheimer's disease risk factors and CD33 is the target of gemtuzumab ozogamicin, an antibody-drug for the treatment of patients with acute myeloid leukemia.
Application	Screen for activators or inhibitors of antibody-mediated signaling for immunotherapy research and drug discovery. Characterize CD33 antibodies and ligands for binding assay.
Host Cell	CHO-K1
Synonyms	Sialic Acid Binding Ig Like Lectin 3 cell line, Gp67 cell line, Myeloid Cell Surface Antigen CD33 cell line, Siglec-3 cell line, Siglec3 cell line, 79935-H, 79935-M, 79935-L
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Storage Stability	Store in liquid nitrogen immediately upon receipt.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200321	79935-H	2 vials	$7865		Add to Cart

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