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Home / Cells / Cell Lines

CD19 / CD20 / Firefly Luciferase CHO Cell Line

SKU : BHC18200094

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BPS Bioscience

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Mfr.No.	78186
Description	Clonal stable CHO cell line constitutively expressing full length human CD19 protein (also known as CVID3, Genbank accession #NM_001770) and human CD20 protein (also known as MS4A1 and FMC7, Genbank accession #NM_021950). This cell line was derived from our CHO-K1 Luciferase cells (Biohippo, #79725), therefore it also constitutively expresses the firefly luciferase reporter. Surface expression of CD19 and CD20 were confirmed by flow cytometry. Mycoplasma testing: The cell line has been screened using the MycoAlert Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as 2 vials of frozen cells. 2 x 10⁶ cells in 1 ml of 10% DMSO
Background	B-lymphocyte antigen CD19 (Cluster of Differentiation 19), also known as B-Lymphocyte Surface Antigen B4 and CVID3, is a transmembrane protein expressed in follicular dendritic cells and all B lineage cells except plasma cells. CD19 plays two major roles in human B cells. It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development and lymphoma diagnosis and can be used as a target for leukemia immunotherapies. CD19-targeted therapies based on T cells that express CD19-specific chimeric antigen receptors (CARs) have been utilized for their antitumor abilities in patients with CD19+ lymphoma and leukemia, such as Non-Hodgkins Lymphoma (NHL), CLL and ALL.CD20 (MS4A1) is a glycosylated phosphoprotein expressed on the cell surface of B cells. Although the functional significance of CD20 is not clear, and CD20 has no known ligands, CD20 has been shown to regulate intracellular calcium levels. CD20 is a highly attractive target antigen for immunotherapy because it is expressed in more than 90% of patients with B-cell lymphoma. First approved in 1997, Rituximab (Rituxan) is a chimeric monoclonal antibody targeting CD20 and has been classified by the World Health Organization as an "Essential Medicine". Since then, additional monoclonal antibodies against CD20 have been approved or are being tested in clinical trials for the treatment of multiple sclerosis (MS), chronic lymphocytic leukemia (CLL), follicular lymphoma, diffuse large B cell lymphoma (DLBCL), rheumatoid arthritis, non-Hodgkin's lymphoma, systemic lupus erythematosus, and myalgic encephalomyelitis (chronic fatigue syndrome). Additionally, more recently, anti-CD20-CD19 bispecific CAR-T cells have been developed to address concerns over potential relapse.
Host Cell	CHO
Species	Human
Synonyms	bi-specific cells, CART cell line, membrane spanning 4-domains A1 cells, B1 cell line, FMC7 cells, CVID5 cell line, Cluster of Differentiation 19 cell line, CD19 molecule cells, B-Lymphocyte Surface Antigen B4 cell line, CVID3 cells
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product.Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200094	78186	2 vials	$11550		Add to Cart

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