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CD155 (PVR) - HEK293 Stable Cell Line

SKU : BHC18200028

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BPS Bioscience

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Mfr.No.	60537
Description	Recombinant HEK293 cell line expressing full length human CD155, also knownas poliovirus receptor (PVR) or nectin-like molecule-5 (NECL-5). Expression is confirmed byWestern Blot. Mycoplasma testing: This cell line has been screened using the MycoAlert Mycoplasma Detection Kit (Lonza, Cat.#LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set(Lonza, Cat. #LT07-518) was used as a positive control. Host Species: human
Background	CD155 is a transmembrane glycoprotein receptor belonging to theimmunoglobulin superfamily. It is highly expressed on dendritic cells, fibroblasts, endothelialcells, and multiple tumor cells including ovarian carcinoma, non-small cell lung, glioblastoma,and colorectal carcinoma. It has a high affinity for a T cell regulatory transmembrane surfaceprotein called TIGIT (T cell immunoglobulin and ITIM domains), and plays a key role in tumorcell invasion and migration. Interaction between CD155 and TIGIT causes immunosuppressiveeffects on CD4+ and CD8+ T cells, which hinders T cell proliferation and function. CD155 alsointeracts with regulatory receptors CD226 (expressed on natural killer (NK) cells, monocytesand CD4+ T cells) and CD96. While CD155-CD226 engagement activates NK cell cytotoxicityand T cell response, CD155-CD96 interaction inhibits NK cell function. Due to these opposingregulatory effects, blockade of CD155-TIGIT and CD155- CD226 interactions are attractivetherapeutic strategies in cancer immunotherapy and autoimmune diseases, respectively.
Application	The CD155/HEK293 Stable Cell Line functions as an antigen-presenting cell (APC) to stimulate TIGIT-specific signaling responses in lymphocytes, such as cell proliferation and cytokine release, or with a TIGIT reporter cell line (Biohippo Cat. #60538).
Host Cell	HEK293
Synonyms	Poliovirus receptor (PVR) and Nectin-like protein 5
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Aqueous solution containing DMSO
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Yu, X., et.al. (2009) The Surface Protein TIGIT Suppresses T cell Activation by Promoting the Generation of Mature Immunoregulatory Dendritic Cells. Nat Immunol. 10: 48-57. 2. Bottino, C., et.al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule. J Exp Med. 198: 557-567. 3. Sloan, K.E., et.al. (2005) CD155/PVR Enhances Glioma Cell Dispersal by Regulating Adhesion Signaling and Focal Adhesion Dynamics. Cancer Res. 65: 10930-37.

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200028	60537	2 vials	$4840		Add to Cart

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