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Home / Cells / Cell Lines

CD137/NF-kappaB Reporter - HEK293 Recombinant Cell Line

SKU : BHC18200173

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BPS Bioscience

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Mfr.No.	79289
Description	Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-kappaB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-kappaB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene. Host Species: human
Background	Human CD137 (4-1BB; TNFRS9) is an inducible co-stimulatory molecule that activates T cells. CD137:CD137L-mediated signaling has been shown to be important for proliferation, effector functions and survivals of T cells. CD137 is also expressed in NK and NKT cells. Accumulating evidence shows a role for CD137:CD137L signaling in inflammation, suggesting that inhibition of this pathway may provide a therapeutic avenue to treat autoimmune and inflammatory diseases. Similarly, antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor properties in cancer patients.
Application	Screen for activators or inhibitors of CD137 signaling in a cellular context Characterize the biological activity of CD137 and its interactions with ligands
Host Cell	HEK293
Synonyms	CD137, 4-1BB
Shipping Temperature	-80°C (dry ice)
Note	Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc.

Product Format	Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200173	79289	2 vials	$12204.50		Add to Cart

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