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Home / Primary Antibodies / Polyclonal Antibodies

CDC42 antibody

SKU : BHA10801525

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Mfr.No.	FNab01530
Background	The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Host	Rabbit
Immunogen	cell division cycle 42 (GTP binding protein, 25kDa)
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CDC42Hs, G25K, TKS

Uniprot	P60953
Gene Id	998
Research Area	Cell Division and Proliferation, Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab01530.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801525	FNab01530	100ug	$260		Add to Cart

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