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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hIGFBP2

    hIGFBP2

    • Strain : Repository Live
    • KI/KO Gene : Igfbp2
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Igf
    • Description : The endogenous
  • hIFNGR1

    hIFNGR1

    • Strain : Embryo cryopres
    • KI/KO Gene : IFNGR1
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ifn
    • Description : The endogenous
  • hIL12B

    hIL12B

    • Strain : Embryo cryopres
    • KI/KO Gene : Il12b
    • Research Application : Cytokine Humani
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hIL11/hIL11RA

    hIL11/hIL11RA

    • Strain : Repository Live
    • KI/KO Gene : Tnfrsf4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : hIL11(NM-HU-204
  • hIL17F

    hIL17F

    • Strain : Embryo cryopres
    • KI/KO Gene : Il17f
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hIL17A(BALB/C)

    hIL17A(BALB/C)

    • Strain : Repository Live
    • KI/KO Gene : Il17a
    • Research Application : Humanized Drug
    • Nomenclature : BALB/cAnSmoc-Il
    • Description : The endogenous
  • hIL1RL2

    hIL1RL2

    • Strain : Sperm cryoprese
    • KI/KO Gene : Apoe
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hIL1RL1

    hIL1RL1

    • Strain : Sperm cryoprese
    • KI/KO Gene : Il1rl1
    • Research Application : Cytokine Humani
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • Rag2/IL2rg-KO/hSIRPA(2)/hCD47

    • Strain : Embryo cryopres
    • KI/KO Gene : SIRPA
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Sir
    • Description : The Rag2 and Il
  • Rag2/IL2rg-KO/hVEGFR2

    Rag2/IL2rg-KO/hVEGFR2

    • Strain : Repository Live
    • KI/KO Gene : IL2RG
    • Nomenclature : C57BL/6Smoc-Il2
    • Research Application : Humanized Drug
    • Description : IL2rg-KO (NM-KO
  • hDR3

    hDR3

    • Strain : Embryo cryopres
    • KI/KO Gene : Tnfrsf25
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : The endogenous
  • hDPP4

    hDPP4

    • Strain : Repository Live
    • KI/KO Gene : Dpp4
    • Research Application : Mers Infection
    • Nomenclature : C57BL/6Smoc-Dpp
    • Description : The endogenous
  • hDMD

    hDMD

    • Strain : Developing
    • KI/KO Gene : Dmd
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Dmd
    • Description : The endogenous
  • hDLL4

    hDLL4

    • Strain : Repository Live
    • KI/KO Gene : Dll4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Dll
    • Description : The endogenous
  • hFAS

    hFAS

    • Strain : Sperm cryoprese
    • KI/KO Gene : Fas
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Fas
    • Description : The endogenous
  • hGLP1R

    hGLP1R

    • Strain : Repository Live
    • KI/KO Gene : Glp1r
    • Research Application : Diabetes Resear
    • Nomenclature : C57BL/6Smoc-Glp
    • Description : The endogenous
  • hGCGR

    hGCGR

    • Strain : Repository Live
    • KI/KO Gene : Cxcr5
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Gcg
    • Description : The endogenous
  • hGPRC5D

    hGPRC5D

    • Strain : Embryo cryopres
    • KI/KO Gene : Adora2a
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Gpr
    • Description : The endogenous
  • hHLA-DPB1*04: 01

    hHLA-DPB1*04: 01

    • Strain : Sperm cryoprese
    • KI/KO Gene : H2-Ab1
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-H2-
    • Description : The endogenous
  • hHLA-DPA1*03: 01

    hHLA-DPA1*03: 01

    • Strain : Repository Live
    • KI/KO Gene : H2-Aa
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-H2-
    • Description : The endogenous
  • hIGHA1

    hIGHA1

    • Strain : Embryo cryopres
    • KI/KO Gene : Ighm
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-s?t
    • Description : The endogenous
  • hIDO1

    hIDO1

    • Strain : Embryo cryopres
    • KI/KO Gene : Ido1
    • Research Application : Immunotherapy
    • Nomenclature : B6;129S-Ido1tm1
    • Description : The endogenous
  • hIL17RA

    hIL17RA

    • Strain : Repository Live
    • KI/KO Gene : Il17ra
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hIL17A/hIL17F

    hIL17A/hIL17F

    • Strain : Embryo cryopres
    • KI/KO Gene : IL17A
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hIL15RA

    hIL15RA

    • Strain : Sperm cryoprese
    • KI/KO Gene : Il15ra
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous