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Home / Antibodies

Caspase-8 Monoclonal Antibody

SKU : BHA13715117

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABM0053
Background	CASP8 (caspase 8) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Clonality	Monoclonal
Description	Mouse Anti-Caspase-8 Monoclonal Antibody
Formulation	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, Liquid solution
Host	Mouse
Immunogen	Recombinant Protein
Immunogen Region	Recombinant Protein
Isotype	Mouse IgG1
Molecular Weight	43, 57 KD
Others	The antibody detects endogenous Caspase-8 protein.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human, Mouse, Rat
Tag	Caspase-8
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000), IF (1:100-1:200), IHC-P (1:200-1:500).

Accession Number	Q14790
Gene Id	841, 841

Concentration	1 mg/ml, 1 mg/ml
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen
Storage Buffer	PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	WB, IF, IHC-P

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715117	ABM0053	100 uL	$229		Add to Cart

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