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Home / Antibodies

BRCA1 Antibody (Breast Marker) (V3240SAF)

SKU : BHA17124902

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NSJ Bioreagents

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Mfr.No.	V3240SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the BRCA1 antibody should be determined by the researcher.

Uniprot	P38398

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the BRCA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE) : 2-5ug/ml for 60 min at RT

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17124902	V3240SAF-100UG	100 ug	$499		Add to Cart

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