YM-58483

Mfr.No.	SIH-606
Description	CRAC channel blocker
Alternative Names	N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide, BTP2
Appearance	Off-white powder
Inchi	1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
Inchikey	XPRZIORDEVHURQ-UHFFFAOYSA-N
Molecular Formula	C15H9F6N5OS
Pubchem Cid	2455
Research Area	Neuroscience \| Neurotransmission \| Ion Channels \| Calcium Channels
Safety Phrases	Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dustS24/25 - Avoid contact with skin and eyesS36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	223499-30-7
Molecular Weight	421.3
Scientific Background	YM-58483 is a calcium release-activated calcium channel blocker. It inhibits antigen-induced histamine release via modulation of mast cell responses. It also is a potent T-cell antiproliferative agent.
Solubility	May be dissolved in DMSO (40 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Zitt. C., et al. (2004) J. Biol. Chem. 279(13): 12427-12437. 2. Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239. 3. K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900384-1	SIH-606-5MG	5 mg	$149		Add to Cart
BHB11900384-2	SIH-606-25MG	25 mg	$556		Add to Cart