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Home / Biochemicals / Small Molecules

YM-08

SKU : BHB11900013

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StressMarq Biosciences Inc.

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Mfr.No.	SIH-122
Alternative Names	(2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
Appearance	Yellow-orange solid
Function	Hsp70 Inhibitor
Mode Of Action	Inhibitor
Molecular Formula	C19H17N3OS2
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	O=C2C(SC(=Cc1ncccc1)N2CC)=C3Sc4ccccc4N3C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	367.49
Scientific Background	YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Solubility	Soluble in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>99% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900013-1	SIH-122-10MG	10 mg	$185		Add to Cart
BHB11900013-2	SIH-122-25MG	25 mg	$371		Add to Cart

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