Vinblastine sulfate

Mfr.No.	SIH-407
Alternative Names	Vincaleukoblastine
Appearance	White powder.
Function	Cell cycle blocker
Inchi	InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
Inchikey	KDQAABAKXDWYSZ-PNYVAJAMSA-N
Mode Of Action	Inhibitor
Molecular Formula	C46H58N4O9•H2SO4
Pubchem Cid	5388983
Sd File	C46H60N4O13S APtclcactv04251417342D 0 0.00000 0.00000 124131 0 0 1 0 0 0 0 0999 V2000 4.4973 4.8839 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.4115 4.6896 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 3.8718 4.1893 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.1606 3.3003 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.7004 3.8006 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.0749 3.1060 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.8614 9.0022 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 6.3424 10.1593 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 7.2368 11.6991 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.2430 4.5129 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6091 4.9977 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6814 2.9771 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6884 6.1482 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8710 6.4907 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7268 2.0161 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4355 5.8471 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0862 5.0601 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8514 1.8607 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0171 2.6404 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9386 7.4854 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9504 4.1776 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7846 3.3980 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9800 6.8389 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2061 2.3393 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1796 5.1036 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5777 5.8848 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7964 6.2829 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3398 2.0210 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3857 1.1454 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2613 1.1913 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8269 8.6914 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4104 9.1473 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7229 2.3106 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5985 2.3565 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5526 3.2321 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5631 0.8756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6090 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4846 0.0459 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9370 9.5518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6031 7.7856 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3385 8.2631 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8609 8.9985 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4472 11.8154 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0548 11.1875 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8162 11.0561 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4685 11.7099 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4314 10.0985 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8291 10.7833 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7725 11.3469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3165 8.0816 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6592 12.4409 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9549 12.2121 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3276 6.8331 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8553 7.5333 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1550 8.0610 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8088 12.7022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0187 12.7554 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2296 10.7357 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 9.0921 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1073 11.0577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8111 11.4319 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2919 12.1837 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0947 13.0380 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2403 12.8408 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2055 7.4133 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2055 5.6813 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.5716 7.0473 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.8395 6.0473 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.1085 6.7373 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3026 6.3573 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5450 7.3565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3736 6.9678 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6797 10.7339 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3951 8.6966 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7170 10.3526 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5738 9.3271 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4697 2.3493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2362 11.6642 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9880 5.6933 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8005 1.6061 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1377 2.7714 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0239 0.4608 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7320 8.3920 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2413 7.4470 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7661 12.5122 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1705 8.0511 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0848 7.8568 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0663 4.5704 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4757 13.0946 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9309 8.1271 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7055 6.5473 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 4.1122 5.9196 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6687 5.2726 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3321 3.6890 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1867 2.4624 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.6711 0.9960 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8176 7.3319 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4435 3.1315 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6930 1.2039 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4868 8.0750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6514 4.1097 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7667 12.5471 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3840 2.1550 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.3946 3.4405 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7539 8.5999 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.1025 7.2870 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8339 6.4675 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7482 6.2732 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8125 9.3112 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6727 11.2379 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2032 11.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2177 10.6805 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4607 11.8536 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3817 12.2528 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5352 2.6057 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6209 2.8001 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0370 5.3842 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4601 11.8187 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4863 10.0846 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3488 9.1001 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9343 9.3768 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4648 10.2597 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9575 4.3836 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.2419 8.6635 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 65 91 2 0 0 0 0 66 91 2 0 0 0 0 67 91 1 0 0 0 0 68 91 1 0 0 0 0 6103 1 6 0 0 0 99103 1 0 0 0 0 5101 1 6 0 0 0 98104 1 0 0 0 0 81104 1 0 0 0 0 95 98 2 0 0 0 0 87105 1 0 0 0 0 83105 1 0 0 0 0 96 99 2 0 0 0 0 100106 1 0 0 0 0 84106 1 0 0 0 0 97100 2 0 0 0 0 9102 1 1 0 0 0 2117 1 0 0 0 0 108117 1 0 0 0 0 79117 1 0 0 0 0 3123 1 0 0 0 0 93123 1 0 0 0 0 94123 1 0 0 0 0 121124 1 0 0 0 0 120124 1 0 0 0 0 111118 1 0 0 0 0 113118 1 0 0 0 0 114118 1 0 0 0 0 1 2 1 0 0 0 0 1 3 1 0 0 0 0 1107 1 0 0 0 0 1 92 1 6 0 0 0 2 5 1 0 0 0 0 2 10 1 6 0 0 0 3 4 1 0 0 0 0 3 11 1 1 0 0 0 4 6 1 0 0 0 0 4115 1 0 0 0 0 4 77 1 1 0 0 0 5 6 1 0 0 0 0 5 98 1 0 0 0 0 6 12 1 0 0 0 0 107108 2 0 0 0 0 71107 1 0 0 0 0 72108 1 0 0 0 0 92 93 1 0 0 0 0 115116 2 0 0 0 0 77 80 1 0 0 0 0 71 86 2 0 0 0 0 94116 1 0 0 0 0 72 87 2 0 0 0 0 86 87 1 0 0 0 0 7 86 1 0 0 0 0 7121 1 0 0 0 0 7100 1 1 0 0 0 7109 1 0 0 0 0 82 99 1 0 0 0 0 121122 2 0 0 0 0 8109 1 0 0 0 0 119122 1 0 0 0 0 110122 1 0 0 0 0 8111 1 0 0 0 0 8112 1 0 0 0 0 119120 2 0 0 0 0 73119 1 0 0 0 0 74120 1 0 0 0 0 110113 1 0 0 0 0 9112 1 0 0 0 0 73 75 2 0 0 0 0 74 76 2 0 0 0 0 9114 1 0 0 0 0 9 78 1 0 0 0 0 75 76 1 0 0 0 0 78 85 1 0 0 0 0 88101 1 0 0 0 0 89102 1 0 0 0 0 67 69 1 0 0 0 0 68 70 1 0 0 0 0 90124 1 0 0 0 0 13 92 1 0 0 0 0 14 92 1 0 0 0 0 15115 1 0 0 0 0 16 93 1 0 0 0 0 17 93 1 0 0 0 0 18 77 1 0 0 0 0 19 77 1 0 0 0 0 20 71 1 0 0 0 0 21 94 1 0 0 0 0 22 94 1 0 0 0 0 23 72 1 0 0 0 0 24116 1 0 0 0 0 25 79 1 0 0 0 0 26 79 1 0 0 0 0 27 79 1 0 0 0 0 28 80 1 0 0 0 0 29 80 1 0 0 0 0 30 80 1 0 0 0 0 31109 1 0 0 0 0 32109 1 0 0 0 0 33 81 1 0 0 0 0 34 81 1 0 0 0 0 35 81 1 0 0 0 0 36 82 1 0 0 0 0 37 82 1 0 0 0 0 38 82 1 0 0 0 0 8 39 1 1 0 0 0 40 83 1 0 0 0 0 41 83 1 0 0 0 0 42 83 1 0 0 0 0 43110 1 0 0 0 0 44110 1 0 0 0 0 45111 1 0 0 0 0 46111 1 0 0 0 0 47112 1 0 0 0 0 48112 1 0 0 0 0 49 73 1 0 0 0 0 50 74 1 0 0 0 0 51113 1 0 0 0 0 52113 1 0 0 0 0 53 84 1 0 0 0 0 54 84 1 0 0 0 0 55 84 1 0 0 0 0 56114 1 0 0 0 0 57114 1 0 0 0 0 58 75 1 0 0 0 0 59 76 1 0 0 0 0 60 78 1 0 0 0 0 61 78 1 0 0 0 0 62 85 1 0 0 0 0 63 85 1 0 0 0 0 64 85 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D1B- Toxic Material Causing Immediate and Serious Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant, Mutagen Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H315- Causes skin irritation. H318- Causes serious eye damage. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Smiles	[C@@]178[C@@H](N(C2=C1C=C(C(=C2)OC)[C@@]5(C3=C(C4=C([NH]3)C=CC=C4)CCN6C[C@@H](C5)C[C@](O)(C6)CC)C(OC)=O)C)[C@](O)([C@H](OC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	143-67-9
Molecular Weight	909.1
Scientific Background	Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with lysosomes.
Solubility	Soluble in DMSO, methanol or water (25 mg/ml).
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46. 2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900195-1	SIH-407-5MG	5 mg	$62		Add to Cart
BHB11900195-2	SIH-407-25MG	25 mg	$241		Add to Cart

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