UNBS-1450

Mfr.No.	T29060
Description	UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2"-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induces apoptotic cell death. UNBS-1450 inhibits NF-kappaB transactivation and triggers apoptosis by cleavage of pro-caspases 8, 9 and 3/7, by decreasing expression of anti-apoptotic Mcl-1 and by recruitment of pro-apoptotic Bak and Bax protein eventually resulting in cell death.
Alternative Names	UNBS 1450
Molecular Formula	C31H43NO9S
Signaling Pathways	Others
Smiles	C(O)(C)12(C)3((C)((C)4(O)(C)(C)(CC3)(CH)(CC4)C=5COC(=O)C5)(CC(C)1(C(C)6((C)(C2)(O(C)7(O)(C)(O6)(O(CH)(C)C(C)78SCC(=O)N8)(H))(H))(H))(H))(H))(H)
Cas Number	676541-58-5
Molecular Weight	605.74
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20418861	T29060	25 mg	-		Add to Quote