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Home / Biochemicals / Small Molecules

TKD Peptide (Hsp70 Peptide): FITC

SKU : BHB11900010

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StressMarq Biosciences Inc.

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Mfr.No.	SIH-119
Appearance	Solid
Function	Hsp70 Peptide
Mode Of Action	Activator
Molecular Formula	FITC-Abu-TKDNNLLGRFELSG
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	1363
Scientific Background	Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (1). The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (2). When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the Cterminal half (3). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (4). Heat shock protein 70 has also been found to have a high degree of plasma membrane localization in tumour cell lines. This is correlated with increased sensitivity to lysis mediated by natural killer (NK) cells. The TKD peptide is a partial hsp70 sequence (TKDNNLLGRFELSG- aa. 450-463) and has identical effects on NK cells as full-length Hsp70 protein, being able to stimulate natural killer cells activity at equivalent concentrations to full-length Hsp70 protein (5). Incubation of peripheral blood lymphocyte cells with TKD plus low-dose interleukin 2 (IL-2) enhances the cytolytic activity of NK cells against Hsp70 membrane-positive tumors, in vitro and in vivo (6). Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Solubility	In aqueous solution
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J.Mol. Evol.38(1): 1-17. 2. Rothman J. (1989), Cell 59: 591 -601. 3. DeLuca-Flaherty et al. (1990) Cell 62: 875-887. 4. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA 89:7290-7294. 5. Multhoff G., et al. (2001) Cell Stress Chaperones 6 (4): 337-344. 6. Krause, S. W. et al. (2004) Clin. Cancer Res. 10(11): 3699-3707.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900010-1	SIH-119A	1 mg	$295		Add to Cart

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