Temozolomide

Mfr.No.	SIH-363
Alternative Names	3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
Appearance	Off white powder
Function	AGT inhibitor
Inchi	InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
Inchikey	BPEGJWRSRHCHSN-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C6H6N6O2
Pubchem Cid	5394
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Toxic Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H350 May cause cancer. H360 May damage fertility or the unborn child. Precautionary Phrases: P201 Obtain special instructions before use. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice or attention.
Smiles	CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	85622-93-1
Molecular Weight	194.2
Scientific Background	Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4).
Solubility	Soluble in DMSO (25 mg/ml, warm) or water (weakly)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.1
Purity	≥99% (TLC); NMR(Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515. 2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463. 3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13. 4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900151-1	SIH-363-25MG	25 mg	$91		Add to Cart
BHB11900151-2	SIH-363-100MG	100 mg	$261		Add to Cart

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Temozolomide

Rate it now..!!