Tamoxifen Citrate

Mfr.No.	SIH-389
Alternative Names	(2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Appearance	White to off-white powder
Function	Autophagy inducer
Inchi	InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
Inchikey	FQZYTYWmlGAPFJ-OQKDUQJOSA-N
Mode Of Action	Inducer
Molecular Formula	C26H29NO•C6H8O7
Pubchem Cid	2733525
Sd File	C32H37NO8 APtclcactv04251417262D 0 0.00000 0.00000 78 79 0 0 0 0 0 0 0 0999 V2000 10.5390 4.4855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9050 5.8515 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 6.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4040 6.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7456 9.0123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3471 9.7026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7331 7.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3301 9.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 8.7400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8059 6.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 4.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4040 4.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1360 7.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7331 10.2400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.9300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 5.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1360 9.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5790 10.1569 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 9.9300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9590 9.0831 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9230 3.7026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5244 3.0123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3471 1.5374 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7456 2.2277 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6490 0.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8890 0.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7130 2.6569 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 2.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0930 1.5831 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5950 3.5825 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2711 6.4855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.4050 2.9855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4050 4.9855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.9050 4.1195 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.1371 4.9855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.6730 2.9855 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4050 6.7176 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2711 5.4855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5390 3.4855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9050 5.8515 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6740 5.2955 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1360 3.2955 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7150 7.2545 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 6.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8671 6.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7331 7.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8671 9.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8671 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5991 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7331 9.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5369 7.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 6.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5991 9.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5369 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 9.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 3.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 9.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 0.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8671 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 7.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 4.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4050 4.9855 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 7.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 3.6200 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 1.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.3270 5.0681 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9284 4.3778 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4876 6.0636 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7974 6.4621 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 36 70 1 0 0 0 0 69 73 1 0 0 0 0 61 73 1 0 0 0 0 33 40 2 0 0 0 0 37 40 1 0 0 0 0 34 41 2 0 0 0 0 35 42 2 0 0 0 0 38 41 1 0 0 0 0 39 42 1 0 0 0 0 62 74 1 0 0 0 0 64 74 1 0 0 0 0 65 74 1 0 0 0 0 71 72 2 0 0 0 0 66 71 1 0 0 0 0 67 71 1 0 0 0 0 68 72 1 0 0 0 0 60 72 1 0 0 0 0 46 66 2 0 0 0 0 47 66 1 0 0 0 0 48 67 2 0 0 0 0 49 67 1 0 0 0 0 50 68 2 0 0 0 0 51 68 1 0 0 0 0 46 52 1 0 0 0 0 47 53 2 0 0 0 0 40 70 1 0 0 0 0 1 70 1 0 0 0 0 2 70 1 0 0 0 0 60 63 1 0 0 0 0 48 54 1 0 0 0 0 49 55 2 0 0 0 0 52 69 2 0 0 0 0 53 69 1 0 0 0 0 50 56 1 0 0 0 0 51 57 2 0 0 0 0 1 41 1 0 0 0 0 2 42 1 0 0 0 0 54 58 2 0 0 0 0 55 58 1 0 0 0 0 56 59 2 0 0 0 0 57 59 1 0 0 0 0 61 62 1 0 0 0 0 32 36 1 0 0 0 0 37 43 1 0 0 0 0 38 44 1 0 0 0 0 39 45 1 0 0 0 0 3 46 1 0 0 0 0 4 47 1 0 0 0 0 5 60 1 0 0 0 0 6 60 1 0 0 0 0 7 48 1 0 0 0 0 8 49 1 0 0 0 0 9 50 1 0 0 0 0 10 51 1 0 0 0 0 11 52 1 0 0 0 0 12 53 1 0 0 0 0 1 75 1 0 0 0 0 1 76 1 0 0 0 0 2 77 1 0 0 0 0 2 78 1 0 0 0 0 13 54 1 0 0 0 0 14 55 1 0 0 0 0 15 56 1 0 0 0 0 16 57 1 0 0 0 0 17 58 1 0 0 0 0 18 59 1 0 0 0 0 19 63 1 0 0 0 0 20 63 1 0 0 0 0 21 63 1 0 0 0 0 22 61 1 0 0 0 0 23 61 1 0 0 0 0 24 62 1 0 0 0 0 25 62 1 0 0 0 0 26 64 1 0 0 0 0 27 64 1 0 0 0 0 28 64 1 0 0 0 0 29 65 1 0 0 0 0 30 65 1 0 0 0 0 31 65 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen, Carcinogen, Reproductive hazard Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H350- May cause cancer. H360- May damage fertility or the unborn child. Precautionary statements: P201- Obtain special instructions before use. P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Smiles	C(C(O)(C(=O)O)CC(=O)O)C(=O)O.C3=C(C(=C(C1=CC=CC=C1)CC)C2=CC=CC=C2)C=CC(=C3)OCCN(C)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	54965-24-1
Molecular Weight	563.65
Scientific Background	Tamoxifen citrate is an endocrine therapy drug used to treat breast cancer. It acts to interrupt estrogen signaling by blocking the estrogen receptor (ER). In vivo, tamoxifen and tamoxafin metabolites bind to estrogen receptors, causing the transcription of estrogen-response genes to be inhibited. In vitro, Tamoxifen is known to inhibit protein kinase C through estrogen receptor-independent antineoplastic effects. This drug therefore has important applications in breast cancer research, particularly in ER+ breast cancers. Recent studies have shown tamoxifen-resistant cells use autophagy as a survival mechanism.
Solubility	Soluble in methanol (50 mg/ml) or ethanol; very slightly soluble in water or acetone.
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.1
Purity	≥99%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Thomas, S. et al. (2011). Breast Cancer Res Treat, 130(2): 437-47. 2. Ma, J. et al. (2014). BMC Cancer, 14: 172. 3. Patel, S. et al. (2012). Int J Radiat Oncol Biol Phys, 82(2): 739-42. 4. Wang, D. et al. (2004). Mol Endocrinol. 402-11.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900177-1	SIH-389-100MG	100 mg	$62		Add to Cart
BHB11900177-2	SIH-389-500MG	500 mg	$141		Add to Cart

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