Sunitinib malate

Mfr.No.	SIH-482
Alternative Names	N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
Appearance	Yellow solid
Function	VEGFR, PDGFR kinase inhibitor
Inchi	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
Inchikey	WINHZLLDWRZWRT-ATVHPVEESA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H27FN4O2
Pubchem Cid	5329102
Sd File	C22H27FN4O2 APtclcactv07281415142D 0 0.00000 0.00000 56 58 0 0 0 0 0 0 0 0999 V2000 2.8660 -2.9372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -1.4372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -3.4372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5547 1.6053 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5325 1.3957 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1807 1.9280 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8956 3.0892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3552 -1.0559 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7433 1.3040 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5660 3.8312 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8511 2.6700 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7369 -3.8312 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5096 -1.7626 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0749 0.2733 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.9372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8335 -0.4757 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2418 0.4371 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2361 0.3309 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4423 -0.6476 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1279 -2.4372 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5992 2.0245 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.9065 1.0729 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1279 -2.4372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5443 -1.6324 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.9372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -2.9372 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8550 -0.6819 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8843 0.8633 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -1.4372 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 12.2029 2.1376 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5443 -3.2419 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5754 -1.1461 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3291 -3.2472 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -0.8172 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -4.0572 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4409 -0.2204 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1020 -1.6219 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9211 -1.3091 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6083 -0.4900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2808 1.6131 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4342 1.8415 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2058 0.9950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7880 2.1797 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0295 1.9347 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2993 0.8212 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0577 1.0662 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9475 1.3536 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7059 1.5986 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5147 3.5785 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3476 2.7991 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0260 3.4156 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9816 4.2913 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1060 4.2469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3112 2.2544 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2668 3.1301 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3911 3.0857 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 3 2 0 0 0 0 2 15 2 0 0 0 0 15 29 1 0 0 0 0 2 25 1 0 0 0 0 25 26 2 0 0 0 0 24 25 1 0 0 0 0 3 26 1 0 0 0 0 26 31 1 0 0 0 0 23 31 1 0 0 0 0 23 24 1 0 0 0 0 20 23 2 0 0 0 0 24 27 2 0 0 0 0 16 27 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 9 17 1 0 0 0 0 18 19 2 0 0 0 0 18 22 1 0 0 0 0 19 32 1 0 0 0 0 8 19 1 0 0 0 0 22 28 1 0 0 0 0 21 22 2 0 0 0 0 4 28 1 0 0 0 0 4 5 1 0 0 0 0 5 30 1 0 0 0 0 6 30 1 0 0 0 0 7 30 1 0 0 0 0 6 11 1 0 0 0 0 7 10 1 0 0 0 0 1 33 1 0 0 0 0 2 34 1 0 0 0 0 3 35 1 0 0 0 0 12 31 1 0 0 0 0 27 36 1 0 0 0 0 13 32 1 0 0 0 0 8 37 1 0 0 0 0 8 38 1 0 0 0 0 8 39 1 0 0 0 0 9 40 1 0 0 0 0 9 41 1 0 0 0 0 9 42 1 0 0 0 0 14 28 1 0 0 0 0 4 43 1 0 0 0 0 4 44 1 0 0 0 0 5 45 1 0 0 0 0 5 46 1 0 0 0 0 6 47 1 0 0 0 0 6 48 1 0 0 0 0 7 49 1 0 0 0 0 7 50 1 0 0 0 0 10 51 1 0 0 0 0 10 52 1 0 0 0 0 10 53 1 0 0 0 0 11 54 1 0 0 0 0 11 55 1 0 0 0 0 11 56 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cardiovascular System ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Reproductive toxicity (Category 1B), H360 Specific target organ toxicity-repeated exposure, Oral (Category 1), H372 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure if swallowed. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P405 Store locked up.
Smiles	C1=CC2=C(C=C1F)C(/C(N2)=O)=C/C3=C(C(=C([NH]3)C)C(NCCN(CC)CC)=O)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	557795-19-4
Molecular Weight	398.5
Scientific Background	Sunitinib malate is a receptor tyrosine kinase inhibitor. It has been shown to target VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, c-KIT, FLT3, CSF-1R, Flk-1, and RET.
Solubility	Soluble in DMSO (40 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥99%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900265-1	SIH-482-5MG	5 mg	$101		Add to Cart
BHB11900265-2	SIH-482-25MG	25 mg	$421		Add to Cart

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