STING Agonist C11

Mfr.No.	T38161
Description	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 uM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1beta, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 uM, respectively), an effect that is dependent on the presence of STING and the IFN-alpha/beta receptor (IFNAR).
Molecular Formula	C19H18N4O3S
Signaling Pathways	Others
Smiles	C(SC=1OC(=NN1)C2=CC=C(C)C=C2)(C(NC(NC)=O)=O)C3=CC=CC=C3
Cas Number	875863-22-2
Molecular Weight	382.44
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20427149	T38161	1 mg	$260	Add to Cart
BHB20427149	T38161	5 mg	$1220	Add to Cart
BHB20427149	T38161	10 mg	$1780	Add to Cart
BHB20427149	T38161	500 ?g	$163	Add to Cart