SKI-178

Mfr.No.	T9014
Description	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 uM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Molecular Formula	C21H22N4O4
Signaling Pathways	GPCR/G Protein, Apoptosis
Smiles	COC1=CC=C(C=C1)C1=NNC(=C1)C(=O)NN=C(/C)C1=CC=C(OC)C(OC)=C1
Cas Number	1259484-97-3
Molecular Weight	394.42
Target	Apoptosis, S1P Receptor

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SKU	Supplier No.	Size	Your price
BHB20447010	T9014	1 mL	$73	Add to Cart
BHB20447010	T9014	2 mg	$41	Add to Cart
BHB20447010	T9014	5 mg	$66	Add to Cart
BHB20447010	T9014	10 mg	$116	Add to Cart
BHB20447010	T9014	25 mg	$226	Add to Cart
BHB20447010	T9014	50 mg	$363	Add to Cart
BHB20447010	T9014	100 mg	$547	Add to Cart
BHB20447010	T9014	500 mg	$1170	Add to Cart