SB202190

Mfr.No.	SIH-473
Alternative Names	FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Appearance	Pale yellow solid
Function	p38 MAP kinase inhibitor
Inchi	InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
Inchikey	NJNKPVPFGLGHPA-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C20H14FN3O
Pubchem Cid	5353940
Sd File	C20H14FN3O APtclcactv07301413032D 0 0.00000 0.00000 39 42 0 0 0 0 0 0 0 0999 V2000 4.7962 -1.8875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5282 -1.8875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6942 -1.0868 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1590 0.5604 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7962 -2.8875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5282 -2.8875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7431 -1.3959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2079 0.2514 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0609 0.0087 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7978 1.6530 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6622 -1.3875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9021 -0.1087 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6622 -3.3875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5133 4.3875 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.6622 -0.3875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8532 0.2003 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1622 1.1514 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7500 1.9604 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9255 3.5784 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7445 1.8559 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3432 2.8739 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3323 2.6649 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9310 3.6830 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6622 -4.3875 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 6.4712 0.2003 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1622 1.1514 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -0.7267 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2592 -1.5775 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0651 -1.5775 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9967 1.2895 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7266 2.9388 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1550 -1.5017 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2879 1.1669 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2592 -3.1975 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0651 -3.1975 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9489 2.6001 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6788 4.2494 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6142 -2.0023 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7472 0.6663 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13 24 1 0 0 0 0 14 19 2 0 0 0 0 15 25 1 0 0 0 0 17 25 1 0 0 0 0 9 25 1 0 0 0 0 16 26 1 0 0 0 0 17 26 1 0 0 0 0 10 26 1 0 0 0 0 7 27 2 0 0 0 0 8 27 1 0 0 0 0 15 16 2 0 0 0 0 11 15 1 0 0 0 0 12 16 1 0 0 0 0 17 18 2 0 0 0 0 1 11 2 0 0 0 0 2 11 1 0 0 0 0 3 12 2 0 0 0 0 4 12 1 0 0 0 0 18 20 1 0 0 0 0 18 21 1 0 0 0 0 1 5 1 0 0 0 0 1 28 1 0 0 0 0 2 6 2 0 0 0 0 2 29 1 0 0 0 0 20 22 2 0 0 0 0 20 30 1 0 0 0 0 21 23 2 0 0 0 0 21 31 1 0 0 0 0 3 7 1 0 0 0 0 3 32 1 0 0 0 0 4 8 2 0 0 0 0 4 33 1 0 0 0 0 5 13 2 0 0 0 0 5 34 1 0 0 0 0 6 13 1 0 0 0 0 6 35 1 0 0 0 0 19 22 1 0 0 0 0 22 36 1 0 0 0 0 19 23 1 0 0 0 0 23 37 1 0 0 0 0 7 38 1 0 0 0 0 8 39 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
Smiles	C4=C(C1=C(NC(N1)=C2C=CC(=O)C=C2)C3=CC=NC=C3)C=CC(=C4)F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	152121-30-7
Molecular Weight	331.3
Scientific Background	SB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.
Solubility	Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420. 2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900257-1	SIH-473-5MG	5 mg	$96		Add to Cart
BHB11900257-2	SIH-473-25MG	25 mg	$365		Add to Cart

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