Rosiglitazone Maleate

Mfr.No.	SIH-379
Alternative Names	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Appearance	White to off-white solid
Function	Insulin sensitizer
Inchi	InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
Inchikey	YASAKCUCGLMORW-UHFFFAOYSA-N
Mode Of Action	Agonist
Molecular Formula	C18H19N3O3S•C4H4O4
Pubchem Cid	77999
Sd File	C18H19N3O3S APtclcactv07171317392D 0 0.00000 0.00000 44 46 0 0 0 0 0 0 0 0999 V2000 3.7321 1.8656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 1.8656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.8656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.8656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -4.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -5.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -5.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -5.6344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 3.3656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -1.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -2.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -2.1344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7990 5.6344 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 2.3656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 0.3656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -3.6344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8255 5.5292 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.0413 4.0975 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -0.6344 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 3.8656 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5686 4.8601 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0468 4.2020 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -2.6344 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5468 5.0680 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3776 3.4588 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -4.1344 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4966 3.2464 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3860 3.9482 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9875 3.2579 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1951 2.1756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 2.1756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1951 0.5556 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 0.5556 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5200 -0.5518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1215 -1.2421 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9441 -2.7170 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3426 -2.0268 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3100 -1.5975 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -1.8244 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6900 -2.6714 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -3.8244 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -5.4444 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 -5.4444 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -6.2544 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9 20 1 0 0 0 0 20 25 1 0 0 0 0 20 21 1 0 0 0 0 9 14 1 0 0 0 0 22 25 1 0 0 0 0 21 24 1 0 0 0 0 17 21 2 0 0 0 0 1 14 2 0 0 0 0 2 14 1 0 0 0 0 18 22 2 0 0 0 0 1 3 1 0 0 0 0 2 4 2 0 0 0 0 3 15 2 0 0 0 0 15 19 1 0 0 0 0 10 19 1 0 0 0 0 10 11 1 0 0 0 0 11 23 1 0 0 0 0 16 23 1 0 0 0 0 12 23 1 0 0 0 0 5 16 2 0 0 0 0 16 26 1 0 0 0 0 5 6 1 0 0 0 0 7 26 2 0 0 0 0 6 8 2 0 0 0 0 22 24 1 0 0 0 0 4 15 1 0 0 0 0 7 8 1 0 0 0 0 20 27 1 0 0 0 0 9 28 1 0 0 0 0 9 29 1 0 0 0 0 13 24 1 0 0 0 0 1 30 1 0 0 0 0 2 31 1 0 0 0 0 3 32 1 0 0 0 0 4 33 1 0 0 0 0 10 34 1 0 0 0 0 10 35 1 0 0 0 0 11 36 1 0 0 0 0 11 37 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 5 41 1 0 0 0 0 6 42 1 0 0 0 0 7 43 1 0 0 0 0 8 44 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C2=C(CC1SC(=O)NC1=O)C=CC(=C2)OCCN(C3=CC=CC=N3)C.O=C(O)C=C/C(=O)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	155141-29-0
Molecular Weight	473.5
Scientific Background	Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is anti-diabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.
Solubility	Soluble in DMSO (3 mg/ml) or DMF (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Werner A.L., & Travaglini M.T. (2001) Pharmacotherapy. 21(9): 1082-99. 2. McMorran M., and Vu D. (2001) CMAJ. 165(1): 82-3, 86-7. 3. Malinowski J.M. & Bolesta S. (2000) Clin. Ther. 22(10): 1151-68. 4. Cheng-Lai A., & Levine A. (2000) Heart Dis. 2(4): 326-33. 5. Knock G.A., et al. (1999) Eur. J. Pharmacol. 368(1): 103-9. 6. Balfour J.A., & Plosker G.L. (1999) Drugs. 57(6): 921-30. 7. Parks D.J., et al. (1998) Bioorg. Med. Chem. Lett. 8(24): 3657-8.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900167-1	SIH-379-10MG	10 mg	$56		Add to Cart
BHB11900167-2	SIH-379-50MG	50 mg	$215		Add to Cart

Rosiglitazone Maleate

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Rosiglitazone Maleate

Rate it now..!!