Roscovitine

Mfr.No.	SIH-472
Alternative Names	2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Appearance	White to off-white solid
Function	p34/cdc2 inhibitor
Inchi	InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
Inchikey	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Mode Of Action	Inhibitor
Molecular Formula	C19H26N6O
Pubchem Cid	160355
Sd File	C19H26N6O APtclcactv07301413032D 0 0.00000 0.00000 52 54 0 0 1 0 0 0 0 0999 V2000 4.2690 2.0002 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 9.2629 1.5002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 -2.4998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -2.4998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 -3.4998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -3.4998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -3.9998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -0.9998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 2.5002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 1.0002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9685 3.4617 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3221 3.9998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 0.5002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 2.3102 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4040 -0.8098 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 3.1202 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 0.5002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 2.0002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -1.9998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 2.0002 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.9900 3.2555 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 2.5002 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.6793 0.6955 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 1.0002 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -0.4998 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 2.5002 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 2.0002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 1.0002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6793 2.3050 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8829 1.5002 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1826 3.8448 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7890 -0.4172 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3905 -1.1074 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 2.6202 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0963 2.8550 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5751 3.5895 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8406 4.0684 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7836 4.4138 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9081 4.4612 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8607 3.5857 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8015 2.9752 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0044 2.9752 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4810 0.4176 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8796 1.1079 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -2.1898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4040 -2.1898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -3.8098 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4040 -3.8098 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -4.6198 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0930 1.0372 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 0.1902 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7130 -0.0367 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9 20 1 0 0 0 0 27 29 1 0 0 0 0 2 29 1 0 0 0 0 21 29 1 0 0 0 0 22 27 1 0 0 0 0 18 22 2 0 0 0 0 23 28 1 0 0 0 0 2 23 2 0 0 0 0 17 24 2 0 0 0 0 18 24 1 0 0 0 0 17 25 1 0 0 0 0 8 25 1 0 0 0 0 18 26 1 0 0 0 0 1 26 1 6 0 0 0 27 28 2 0 0 0 0 17 28 1 0 0 0 0 11 21 1 0 0 0 0 12 21 1 0 0 0 0 8 19 1 0 0 0 0 1 9 1 0 0 0 0 1 10 1 0 0 0 0 3 19 2 0 0 0 0 4 19 1 0 0 0 0 10 13 1 0 0 0 0 3 5 1 0 0 0 0 4 6 2 0 0 0 0 5 7 2 0 0 0 0 6 7 1 0 0 0 0 14 20 1 0 0 0 0 15 25 1 0 0 0 0 16 26 1 0 0 0 0 2 30 1 0 0 0 0 21 31 1 0 0 0 0 8 32 1 0 0 0 0 8 33 1 0 0 0 0 1 34 1 0 0 0 0 11 35 1 0 0 0 0 11 36 1 0 0 0 0 11 37 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 9 41 1 0 0 0 0 9 42 1 0 0 0 0 10 43 1 0 0 0 0 10 44 1 0 0 0 0 3 45 1 0 0 0 0 4 46 1 0 0 0 0 5 47 1 0 0 0 0 6 48 1 0 0 0 0 7 49 1 0 0 0 0 13 50 1 0 0 0 0 13 51 1 0 0 0 0 13 52 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	[C@H](NC2=NC1=C(N=C[N]1C(C)C)C(=N2)NCC3=CC=CC=C3)(CO)CC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	186692-46-6
Molecular Weight	354.4
Scientific Background	Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating.
Solubility	Soluble in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥95% (HPLC, TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900256-1	SIH-472-2MG	2 mg	$58		Add to Cart
BHB11900256-2	SIH-472-10MG	10 mg	$233		Add to Cart

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