PI3-Kinase ? Inhibitor 2

Mfr.No.	T35525
Description	Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kalpha, beta, and delta are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kgamma is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kalpha inhibitor 2 is a selective inhibitor of PI3Kalpha with IC50 values of 2, 16, 660, and 220 nM for the alpha, beta, gamma, and 2Cbeta isoforms, respectively. It inhibits PKA, KDR, PKCalpha, and cyclin E/Cdk2 significantly less effectively (IC50 = 91, 3.4, 466, and 28 uM, respectively). PI3Kalpha inhibitor 2 inhibits A375 melanoma cell proliferation with an IC50 value of 580 nM.
Molecular Formula	C16H15N3O2S
Signaling Pathways	Others
Smiles	OC=1C=C(C2=NC(=C3C(=N2)C=CS3)N4CCOCC4)C=CC1
Cas Number	371943-05-4
Molecular Weight	313.37
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20424945	T35525	1 mg	$125	Add to Cart
BHB20424945	T35525	5 mg	$518	Add to Cart
BHB20424945	T35525	10 mg	$893	Add to Cart
BHB20424945	T35525	500 ?g	$68	Add to Cart