PD325901

Mfr.No.	SIH-507
Alternative Names	PD 0325901, PD-325901, N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Appearance	Off-white solid
Function	MEK kinase inhibitor
Inchi	InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
Inchikey	SUDAHWBOROXANE-SECBINFHSA-N
Mode Of Action	Inhibitor
Molecular Formula	C16H14F3IN2O4
Pubchem Cid	9826528
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Specific target organ toxicity -repeated exposure (Category 2), H373 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H373 May cause damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P314 Get medical advice/ attention if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Smiles	C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	391210-10-9
Molecular Weight	482.2
Scientific Background	PD325901 is a potent MEK1 and MEK2 inhibitor. Specifically, it has been shown to suppress phosphorylation of ERK1/2 in murine colon 26 cells, as well as, its downstream target, ribosomal S6 kinase, in a dose-dependent manner.
Solubility	Soluble to 25 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Barrett S.D., et al. (2008) Bioorganic. Med. Chem. Letters. 18(24): 6501–6504. 2. Ciuffreda L., et al. (2009) Neoplasia. 11(8): 720–731.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900290-1	SIH-507-5MG	5 mg	$107		Add to Cart
BHB11900290-2	SIH-507-25MG	25 mg	$398		Add to Cart

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