Okadaic acid

Mfr.No.	SIH-521
Alternative Names	9,10-Deepithio-9,10-didehydroacanthifolicin
Appearance	White crystalline solid
Function	PP1 and PP2A inhibitor
Inchi	InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
Inchikey	QNDVLZJODHBUFM-WFXQOWMNSA-N
Mode Of Action	Inhibitor
Molecular Formula	C44H68O13
Pubchem Cid	446512
Sd File	C44H68O13 APtclcactv07301413342D 0 0.00000 0.00000 125131 0 0 1 0 0 0 0 0999 V2000 5.1767 -0.1106 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.1767 1.8894 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.1704 5.9553 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.2947 3.4587 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.9024 5.9487 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 3.4007 1.8963 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.9101 7.9486 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.2986 4.4587 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.6767 -1.6494 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.2198 -6.8171 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 6.4455 -4.1810 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.0388 -5.0945 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.8131 -7.7306 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 7.8021 -7.5216 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 9.3845 -8.2261 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.1665 4.9553 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7967 -7.4171 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3063 6.4587 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8986 4.9487 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4401 -4.0765 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6430 -6.2171 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5754 -8.8139 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 1.6901 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4369 5.5820 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5664 -8.4016 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1287 -7.0217 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5655 -9.9486 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0427 0.3894 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0427 1.3894 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3677 -0.6984 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7704 6.4453 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7742 7.4453 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6767 -1.6494 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7781 8.4453 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7819 9.4453 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9178 9.9486 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0499 9.4520 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0443 -5.1991 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4009 -8.5397 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3954 -8.4351 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5405 1.3863 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4345 4.9620 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8186 -7.8352 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.1935 -7.6383 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9668 -8.9306 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9722 -9.0351 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0383 6.4520 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3926 2.9379 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6375 -6.1126 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3312 -9.4321 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2645 -2.4584 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8577 -3.3720 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3107 0.3894 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.1928 2.9309 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9857 -0.6984 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0422 7.4520 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0460 8.4520 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.6266 -5.9035 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2144 -6.7126 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2253 -6.9216 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3107 1.3894 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5247 3.4345 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9161 2.3087 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7761 1.0753 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2548 -0.1932 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6533 0.4971 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6533 1.2818 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2548 1.9720 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5026 6.7641 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6322 5.6474 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0333 3.8794 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4381 5.6366 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0577 -0.1614 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8013 -0.9505 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8608 2.2011 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7604 4.1508 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3763 4.3719 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7775 5.0607 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9802 5.8619 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3813 6.5506 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3844 7.3353 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9885 8.0271 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0702 -1.7783 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7415 -2.2660 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2891 -1.5524 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9879 7.8619 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3891 8.5506 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6184 6.9944 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7705 6.7707 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9942 5.9229 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2786 4.9511 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8962 4.3287 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5186 4.9463 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3921 9.3353 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9962 10.0271 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8811 -2.3936 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3182 10.4220 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5211 10.4251 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8401 10.0354 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4389 9.3467 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5223 4.0545 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9890 3.1225 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6977 -3.6146 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8841 -5.0057 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2411 -3.4368 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4487 -7.2290 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0543 -6.9552 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0875 -4.5806 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4427 -5.0491 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8436 -8.8114 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5718 -9.1356 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3522 -9.0536 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9970 -8.5851 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9731 -7.4880 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3539 -7.1453 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6258 -6.8211 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5049 -4.6931 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0567 -4.0117 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3752 -3.4599 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5782 -5.6005 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0264 -6.2819 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7078 -6.8337 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2110 -8.3123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0738 -9.1783 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9399 -9.3154 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 53 1 6 0 0 0 53 61 1 0 0 0 0 2 54 1 0 0 0 0 4 54 1 0 0 0 0 1 55 1 0 0 0 0 9 55 1 0 0 0 0 47 56 1 0 0 0 0 7 56 1 1 0 0 0 7 57 1 0 0 0 0 37 57 1 0 0 0 0 6 41 1 6 0 0 0 23 41 1 0 0 0 0 8 42 1 1 0 0 0 24 42 1 0 0 0 0 10 58 1 1 0 0 0 12 58 1 0 0 0 0 10 59 1 0 0 0 0 14 59 1 0 0 0 0 13 43 1 1 0 0 0 25 43 1 0 0 0 0 15 44 1 6 0 0 0 26 44 1 0 0 0 0 45 46 1 0 0 0 0 45 50 1 0 0 0 0 27 46 2 0 0 0 0 1 28 1 0 0 0 0 1 30 1 0 0 0 0 2 61 1 0 0 0 0 2 29 1 0 0 0 0 2 63 1 1 0 0 0 6 61 1 0 0 0 0 61 64 1 0 0 0 0 28 29 1 0 0 0 0 28 65 1 0 0 0 0 28 66 1 0 0 0 0 29 67 1 0 0 0 0 29 68 1 0 0 0 0 3 47 1 0 0 0 0 5 47 1 0 0 0 0 47 69 1 0 0 0 0 3 16 1 0 0 0 0 3 18 1 6 0 0 0 3 70 1 0 0 0 0 4 8 1 0 0 0 0 4 48 1 0 0 0 0 4 71 1 6 0 0 0 5 31 1 0 0 0 0 5 19 1 1 0 0 0 5 72 1 0 0 0 0 30 33 1 0 0 0 0 30 73 1 0 0 0 0 30 74 1 0 0 0 0 6 48 1 0 0 0 0 6 75 1 0 0 0 0 7 32 1 0 0 0 0 7 34 1 0 0 0 0 8 16 1 0 0 0 0 8 76 1 0 0 0 0 16 77 1 0 0 0 0 16 78 1 0 0 0 0 31 32 1 0 0 0 0 31 79 1 0 0 0 0 31 80 1 0 0 0 0 32 81 1 0 0 0 0 32 82 1 0 0 0 0 9 33 1 0 0 0 0 33 83 1 0 0 0 0 33 84 1 0 0 0 0 48 62 2 0 0 0 0 9 51 1 1 0 0 0 9 85 1 0 0 0 0 34 35 1 0 0 0 0 34 86 1 0 0 0 0 34 87 1 0 0 0 0 18 88 1 0 0 0 0 18 89 1 0 0 0 0 18 90 1 0 0 0 0 19 91 1 0 0 0 0 19 92 1 0 0 0 0 19 93 1 0 0 0 0 35 36 1 0 0 0 0 35 94 1 0 0 0 0 35 95 1 0 0 0 0 51 52 2 0 0 0 0 51 96 1 0 0 0 0 36 37 1 0 0 0 0 36 97 1 0 0 0 0 36 98 1 0 0 0 0 37 99 1 0 0 0 0 37100 1 0 0 0 0 62101 1 0 0 0 0 62102 1 0 0 0 0 10 13 1 0 0 0 0 10 60 1 0 0 0 0 11 12 1 0 0 0 0 11 52 1 0 0 0 0 11 20 1 1 0 0 0 11103 1 0 0 0 0 12 38 1 0 0 0 0 12104 1 6 0 0 0 52105 1 0 0 0 0 13 39 1 0 0 0 0 13106 1 0 0 0 0 14 40 1 0 0 0 0 14 17 1 6 0 0 0 14107 1 0 0 0 0 38 49 1 0 0 0 0 38108 1 0 0 0 0 38109 1 0 0 0 0 39 40 1 0 0 0 0 39110 1 0 0 0 0 39111 1 0 0 0 0 40112 1 0 0 0 0 40113 1 0 0 0 0 49 60 2 0 0 0 0 60114 1 0 0 0 0 21 49 1 0 0 0 0 15 17 1 0 0 0 0 17115 1 0 0 0 0 17116 1 0 0 0 0 20117 1 0 0 0 0 20118 1 0 0 0 0 20119 1 0 0 0 0 15 22 1 0 0 0 0 15 46 1 0 0 0 0 21120 1 0 0 0 0 21121 1 0 0 0 0 21122 1 0 0 0 0 22123 1 0 0 0 0 22124 1 0 0 0 0 22125 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H315 Causes skin irritation Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P361 Remove/Take off immediately all contaminated clothing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
Smiles	[C@@]45(OC3[C@H](O[C@H]([C@@H](O)C[C@@H](C2O[C@]1(OCCCC1)CC[C@H]2C)C)C([C@H]3O)=C)CC4)O[C@H](CC5)C=C[C@H]([C@H]7O[C@]6(O[C@@H](CC[C@H]6O)C[C@](O)(C)C(O)=O)C=C(C7)C)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	78111-17-8
Molecular Weight	805
Scientific Background	Okadaic acid is a potent and selective inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible inhibitor.
Solubility	Soluble in chloroform, ethanol, methanol, acetone or ethyl acetate
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.0001
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Cohen P., Holmes C.F., & Tsukitani Y. (1990) Trends Biochem. 15(3): 98–102.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900302-1	SIH-521-20UG	20 ug	$73		Add to Cart
BHB11900302-2	SIH-521-100UG	100 ug	$270		Add to Cart

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