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NpFR1

SKU : BHB11900023

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StressMarq Biosciences Inc.

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Mfr.No.	SIH-181
Appearance	Red Solid
Function	Reversible fluorescence intensity-based redox sensor
Inchi	InChI=1S/C23H21N5O4/c1-3-5-10-28-21(30)13-8-6-7-12-16(13)14(22(28)31)11-15-18(12)27(9-4-2)19-17(24-15)20(29)26-23(3
Inchikey	C5(C2=C1C(=CC4=C(C1=CC=C2)N(C3=NC(NC(C3=N4)=O)=O)CCC)C(N5CCCC)=O)=O
Mode Of Action	Redox Probe
Molecular Formula	C23H21N5O4
Sd File	C23H21N5O4 APtclcactv05041518372D 0 0.00000 0.00000 53 57 0 0 0 0 0 0 0 0999 V2000 7.2613 -2.4403 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3842 -1.9776 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3681 -0.9361 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2342 -0.4361 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2342 0.5639 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3681 1.0639 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5021 0.5639 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5021 -0.4361 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5921 -0.9429 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5841 -1.9845 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4862 -2.5053 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5921 1.0708 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5841 2.1124 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6362 2.6403 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6278 3.7253 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5675 4.2678 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5029 3.7181 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4862 2.6332 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3842 2.1054 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3746 4.2080 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7599 4.2219 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7319 0.5608 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8602 1.0507 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.5408 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0936 -0.9308 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1071 -1.9225 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9828 -2.4053 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0025 -3.4051 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8782 -3.8880 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8979 -4.8878 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9559 -0.4245 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2933 -3.4398 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7711 0.8739 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0588 -0.6267 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0460 -2.2924 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4886 -3.1253 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5699 4.8878 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3389 0.0813 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1359 0.0905 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2532 1.5303 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4562 1.5211 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6838 1.0741 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4667 0.2246 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3162 0.0074 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5954 -2.5009 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1833 -1.8186 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3899 -3.3095 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8019 -3.9918 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4907 -3.9836 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0787 -3.3013 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2780 -4.9000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9101 -5.5077 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5177 -4.8756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 2 0 0 0 0 3 4 1 0 0 0 0 4 5 2 0 0 0 0 5 6 1 0 0 0 0 6 7 2 0 0 0 0 7 8 1 0 0 0 0 3 8 1 0 0 0 0 8 9 2 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 2 11 1 0 0 0 0 7 12 1 0 0 0 0 12 13 1 0 0 0 0 13 14 2 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 13 18 1 0 0 0 0 18 19 2 0 0 0 0 6 19 1 0 0 0 0 17 20 2 0 0 0 0 15 21 2 0 0 0 0 12 22 1 0 0 0 0 22 23 1 0 0 0 0 23 24 1 0 0 0 0 4 25 1 0 0 0 0 25 26 1 0 0 0 0 1 26 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 25 31 2 0 0 0 0 1 32 2 0 0 0 0 5 33 1 0 0 0 0 9 34 1 0 0 0 0 10 35 1 0 0 0 0 11 36 1 0 0 0 0 16 37 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 27 45 1 0 0 0 0 27 46 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 M END $$$$ Getting started ... ; Documentation ; Blog ; Contact ; Disclaimer ; Privacy Statement
Research Area	Cancer ; Oxidative Stress
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C1(N(C(C2=CC5=C(C3=CC=CC1=C23)N(C4=NC(NC(C4=N5)=O)=O)CCC)=O)CCCC)=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	431.45
Scientific Background	NpFR1, or napthalimide-flavin redox sensor 1, is a novel flavin molecule that exhibits a greater than 100-fold increase in fluorescence upon oxidation, and is easily reversible. In the oxidative form, is shows a maximum absorption at 395 and 463nm, max admission at 545nm. Treatment with a mild reducing agent (including sodium thiosulfate, sodium cyanoborohydride, DTT and glutathione) gave the reduced form which exhibited 110-fold lower absorbance, and 125-fold lower emission. Re-oxidation to its original fluorescence can be achieved by air or by hydrogen peroxide.
Solubility	Soluble in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Blue Ice or 4ºC
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Yeow J., Kaur A.K., Anscomb M.D., and New E.J. (2014) Chem. Commun. 50: 8181-8184.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900023-1	SIH-181-1MG	1 mg	$477		Add to Cart

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