Niclosamide

Mfr.No.	SIH-406
Alternative Names	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Appearance	Pale yellow solid
Function	Autophagy inducer
Inchi	InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Inchikey	RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Mode Of Action	Inducer
Molecular Formula	C13H8Cl2N2O4
Pubchem Cid	4477
Sd File	C13H8Cl2N2O4 APtclcactv04251417342D 0 0.00000 0.00000 29 30 0 0 0 0 0 0 0 0999 V2000 5.4641 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 3.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1951 0.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3291 2.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 3.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -4.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 2.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 4.0000 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -0.5000 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -4.0000 0.0000 O 0 5 0 0 0 0 0 0 0 0 0 0 3.7321 -3.5000 0.0000 N 0 3 0 0 0 0 0 0 0 0 0 0 6.0010 2.1900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1951 3.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 4.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 -0.6900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3291 -2.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 -2.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9 18 1 0 0 0 0 9 10 1 0 0 0 0 1 9 2 0 0 0 0 18 21 1 0 0 0 0 15 18 2 0 0 0 0 2 10 2 0 0 0 0 10 17 1 0 0 0 0 1 11 1 0 0 0 0 12 21 1 0 0 0 0 2 3 1 0 0 0 0 11 19 1 0 0 0 0 12 13 2 0 0 0 0 4 12 1 0 0 0 0 5 13 1 0 0 0 0 13 20 1 0 0 0 0 4 6 2 0 0 0 0 5 14 2 0 0 0 0 14 23 1 0 0 0 0 16 23 2 0 0 0 0 22 23 1 0 0 0 0 3 11 2 0 0 0 0 6 14 1 0 0 0 0 1 24 1 0 0 0 0 7 21 1 0 0 0 0 2 25 1 0 0 0 0 8 17 1 0 0 0 0 3 26 1 0 0 0 0 4 27 1 0 0 0 0 5 28 1 0 0 0 0 6 29 1 0 0 0 0 M CHG 2 22 -1 23 1 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C2=C(C(NC1=C(C=C([N+](=O)[O-])C=C1)Cl)=O)C(=CC=C2Cl)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	50-65-7
Molecular Weight	327.12
Scientific Background	Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
Solubility	Soluble to 25 mM in ethanol and to 10 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	1
Purity	>98% (TLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900194-1	SIH-406-1G	1 g	$44		Add to Cart

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