Necrostatin

Mfr.No.	SIH-213
Alternative Names	5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1
Appearance	Light Yellow Solid
Function	Necroptosis inhibitor
Inchi	InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
Inchikey	TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C13H13N3OS
Pubchem Cid	2828334
Published Application	In vitro inhibition ; In vitro inhibition ; Cell viability assay
Published Species Reactivity	Human ; Human ; Human
Pubmed Id	29152118 ; 27592300 ; 25341043
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	4311-88-0
Molecular Weight	259.33
Scientific Background	Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
Solubility	Soluble to 15 mM in ethanol, and to 30 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573. 2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714. 3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900042-1	SIH-213-10MG	10 mg	$75		Add to Cart
BHB11900042-2	SIH-213-50MG	50 mg	$215		Add to Cart