MG-132

Mfr.No.	SIH-326
Alternative Names	N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Appearance	White solid
Function	Proteasome Inhibitor
Inchi	InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
Inchikey	TZYWCYJVHRLUCT-VABKMULXSA-N
Mode Of Action	Inhibitor
Molecular Formula	C26H41N3O5
Pubchem Cid	462382
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Smiles	CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	133407-82-6
Molecular Weight	475.6
Scientific Background	Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable
Solubility	Soluble in 45 mg/ml DMSO, DMF and ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900115-1	SIH-326-5MG	5 mg	$40		Add to Cart
BHB11900115-2	SIH-326-25MG	25 mg	$141		Add to Cart