Metformin Hydrochloride

Mfr.No.	SIH-395
Alternative Names	N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Appearance	White crystalline powder.
Function	Autophagy inducer
Inchi	InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
Inchikey	OETHQSJEHLVLGH-UHFFFAOYSA-N
Mode Of Action	Inducer
Molecular Formula	C4H11N5•HCl
Pubchem Cid	14219
Sd File	C4H12ClN5 APtclcactv04251417322D 0 0.00000 0.00000 22 19 0 0 0 0 0 0 0 0999 V2000 2.2020 0.0000 0.0000 H 0 3 0 0 0 0 0 0 0 0 0 0 4.5571 3.2731 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4040 3.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1771 4.3469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6210 5.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 5.9300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3810 5.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8671 3.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 5.3100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6719 2.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5369 4.9300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 2.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9399 2.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 3.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 3.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2020 0.0000 0.0000 Cl 0 5 0 0 0 0 0 0 0 0 0 0 0.5369 4.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 2.8100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0010 4.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 4.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.1350 2.8100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8 20 1 0 0 0 0 9 20 1 0 0 0 0 15 20 1 0 0 0 0 15 21 1 0 0 0 0 16 21 2 0 0 0 0 15 22 2 0 0 0 0 10 22 1 0 0 0 0 16 18 1 0 0 0 0 11 18 1 0 0 0 0 12 18 1 0 0 0 0 16 19 1 0 0 0 0 13 19 1 0 0 0 0 14 19 1 0 0 0 0 2 8 1 0 0 0 0 3 8 1 0 0 0 0 4 8 1 0 0 0 0 5 9 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 M CHG 2 1 1 17 -1 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H315- Causes skin irritation. H319- Causes serious eye irritation. Precautionary statements: P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Smiles	[H+].CN(C)C(N=C(N)N)=N.[Cl-]
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	1115-70-4
Molecular Weight	165.6
Scientific Background	Metformin Hydrochloride is an antidiabetic agent which reduces blood-glucose levels as well as improves insulin sensitivity. Metformin has also been shown to inhibit hepatic gluconeogenesis via activation of LKB1-AMPK (AMP-activated protein kinase) pathway. The activation of this pathway has also been seen to have an antiproliferative and pro-apoptotic effect in cancer cells. Lastly, Metformin is believed to induce autophagy through inhibition of the mTORC1 pathway.
Solubility	Soluble to 100 mM in water and to 50 mM in DMSO.
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	5
Purity	≥97%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Kirpichnikov D., et al. (2002). Ann Intern Med. 137(1): 25-33. 2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106. 3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36. 4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900183-1	SIH-395-5G	5 g	$44		Add to Cart

Metformin Hydrochloride

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