MD001

Mfr.No.	T35800
Description	MD001 is a dual agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma.1 It binds to PPARalpha and PPARgamma (Kds = 9.55 and 0.14 uM, respectively) but does not bind to PPARbeta/delta at concentrations up to 500 uM. It increases transcriptional activity of PPARalpha and PPARgamma in a cell-based luciferase reporter assay when used at a concentration of 10 uM. MD001 (10 uM) increases expression of PPARalpha, PPARgamma, and retinoid X receptor (RXR), as well as PPARalpha and PPARgamma target genes, in HepG2 cells. It increases glucose consumption as well as expression of GLUT2 and GLUT4 in HepG2 and 3T3-L1 cells, respectively, in a concentration-dependent manner. MD001 (20 mg/kg) decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.
Molecular Formula	C25H18O5
Signaling Pathways	Others
Smiles	C(/C=C/C1=CC=CC=C1)(=O)C2=C(C=3C(OC2=O)=C(C)C(O)=CC3O)C4=CC=CC=C4
Cas Number	2254605-76-8
Molecular Weight	398.41
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20425182	T35800	10 mg	$1080		Add to Cart