Lysophosphatidic Acid, Sodium Salt

Mfr.No.	SIH-403
Alternative Names	Oleoyl-lysophosphatidic acid sodium salt
Appearance	White powder.
Function	Autophagy inhibitor
Inchi	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
Inchikey	WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Mode Of Action	Inhibitor
Molecular Formula	C21H41O7P*Na
Pubchem Cid	5311263
Sd File	C21H41O7P APtclcactv04251417422D 0 0.00000 0.00000 70 69 0 0 0 0 0 0 0 0999 V2000 5.1350 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 -2.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 -2.7500 0.0000 P 0 0 0 0 0 0 0 0 0 0 0 0 3.9030 -3.6160 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -3.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9030 -1.8840 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -1.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 -2.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5991 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5991 -3.7500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4651 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3312 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1972 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0632 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9292 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7953 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6613 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5273 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3933 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3933 -1.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2594 -0.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2594 0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1254 0.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1254 1.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.9914 2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.9914 3.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8574 3.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7365 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5335 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -2.9400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2130 -1.3470 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5380 -1.9400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5380 -0.9400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4685 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2656 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8637 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0666 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9326 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7297 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5957 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7987 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6647 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4617 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3278 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5307 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3967 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1938 -3.2249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0598 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2628 -1.7751 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5273 -3.3700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9303 -2.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1813 -0.6674 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7828 -1.3577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4714 -1.3326 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8699 -0.6423 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0473 0.8326 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6488 0.1423 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3374 0.1674 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7360 0.8577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9133 2.3326 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5148 1.6423 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2035 1.6674 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6020 2.3577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7794 3.8326 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3808 3.1423 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1674 3.2131 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3944 4.0600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5474 4.2869 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 1 0 0 0 0 3 4 2 0 0 0 0 3 5 1 0 0 0 0 3 6 1 0 0 0 0 1 7 1 0 0 0 0 7 8 1 0 0 0 0 7 9 1 0 0 0 0 9 10 1 0 0 0 0 10 11 1 0 0 0 0 11 12 2 0 0 0 0 11 13 1 0 0 0 0 13 14 1 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 23 1 0 0 0 0 23 24 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 1 30 1 0 0 0 0 1 31 1 0 0 0 0 5 32 1 0 0 0 0 6 33 1 0 0 0 0 7 34 1 0 0 0 0 8 35 1 0 0 0 0 9 36 1 0 0 0 0 9 37 1 0 0 0 0 13 38 1 0 0 0 0 13 39 1 0 0 0 0 14 40 1 0 0 0 0 14 41 1 0 0 0 0 15 42 1 0 0 0 0 15 43 1 0 0 0 0 16 44 1 0 0 0 0 16 45 1 0 0 0 0 17 46 1 0 0 0 0 17 47 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 50 1 0 0 0 0 19 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 56 1 0 0 0 0 23 57 1 0 0 0 0 24 58 1 0 0 0 0 24 59 1 0 0 0 0 25 60 1 0 0 0 0 25 61 1 0 0 0 0 26 62 1 0 0 0 0 26 63 1 0 0 0 0 27 64 1 0 0 0 0 27 65 1 0 0 0 0 28 66 1 0 0 0 0 28 67 1 0 0 0 0 29 68 1 0 0 0 0 29 69 1 0 0 0 0 29 70 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C(O[P](=O)(O)O)C(O)COC(=O)CCCCCCCC=C/CCCCCCCC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	22556-62-3
Molecular Weight	458.5
Scientific Background	Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
Solubility	Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9. 2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900191-1	SIH-403-5MG	5 mg	$69		Add to Cart
BHB11900191-2	SIH-403-25MG	25 mg	$275		Add to Cart

Lysophosphatidic Acid, Sodium Salt

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