KAAD-Cyclopamine

Mfr.No.	T35558
Description	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated oncogene 1 (Gli1) and cytosolic MMP-9, pERK1, and pERK2 proteins in a dose-dependent manner. Cyclopamine-KAAD also increases TRAIL-mediated cell death in NCH82 and NCH89 human glioblastoma cultures and upregulates expression of the death receptors DR4 and DR5 in LN229 and U251 glioma cells.
Alternative Names	Cyclopamine-KAAD
Molecular Formula	C44H63N3O4
Signaling Pathways	Others
Smiles	C(CH)1(C)2(C(C)=C3(C)(CC2)((C)4((C)(C3)((C)5(C)C(=CC4)CC(=O)CC5)(H))(H))(H))O(C)6((C)1(N(CCNC(CCCCCNC(CCC7=CC=CC=C7)=O)=O)C(CH)(C)C6)(H))(H)
Cas Number	306387-90-6
Molecular Weight	697.99
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20424977	T35558	1 mg	$2170		Add to Cart