IU1

Mfr.No.	SIH-329
Alternative Names	1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone
Appearance	Beige Solid
Function	Usp-14 inhibitor
Inchi	InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
Inchikey	JUWDSDKJBMFLHE-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C18H21FN2O
Pubchem Cid	675434
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H303 – May be harmful if swallowed H318 – Causes serious eye damage Precautionary Statements: P280 – Wear protective gloves/ eye protection/ face protection P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses.
Smiles	CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	314245-33-5
Molecular Weight	300.4
Scientific Background	Selective inhibitor of Usp14 (IC50<4 M). Enhances proteasome activity and substrate proteolysis. Cell permeable.
Solubility	Soluble in 30 mg/ml DMSO, 15 mg/ml Ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Lee B.H., et al. (2010) Nature 467: 1179. 2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900118-1	SIH-329-10MG	10 mg	$87		Add to Cart
BHB11900118-2	SIH-329-50MG	50 mg	$341		Add to Cart