Irinotecan HCl

Mfr.No.	SIH-243
Alternative Names	(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11
Appearance	Yellow solid
Function	Topoisomerase I inhibitor
Inchi	InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)1
Inchikey	UWKQSNNFCGGAFS-XIFFEERXSA-N
Mode Of Action	Inducer
Molecular Formula	C33H38N4O6•HCl
Pubchem Cid	74990
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302
Smiles	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	100286-90-6
Molecular Weight	623.14
Scientific Background	Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).
Solubility	Soluble to 50 mg/ml in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.25
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388. 2. O'Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900065-1	SIH-243-50MG	50 mg	$114		Add to Cart
BHB11900065-2	SIH-243-250MG	250 mg	$415		Add to Cart

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