GSK690693 Hydrochloride

Mfr.No.	SIH-448
Alternative Names	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Appearance	White to beige solid
Function	AKT kinase inhibitor
Inchi	InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
Inchikey	KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Mode Of Action	Inhibitor
Molecular Formula	C21H27N7O3
Pubchem Cid	16725726
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute toxicity, Oral (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Smiles	CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	937174-76-0
Molecular Weight	425.5
Scientific Background	GSK690693 Hydrochloride is an ATP-competitive pan-Akt kinase inhibitor. It is derived from aminofurazan. It has shown to produce antiproliferative and apoptotic effects in tumor cell lines.
Solubility	Soluble to 50 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Heerding D.A., et al. (2008) J. Med. Chem. 51(18): 5663–5679. 2. Rhodes N., et al. (2008) Cancer Res. 68(7): 2366–2374.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900232-1	SIH-448-5MG	5 mg	$129		Add to Cart
BHB11900232-2	SIH-448-25MG	25 mg	$510		Add to Cart

GSK690693 Hydrochloride

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