Gefitinib

Mfr.No.	SIH-445
Alternative Names	N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Appearance	Solid
Function	EGFR Kinase inhibitor
Inchi	InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
Inchikey	XGALLCVXEZPNRQ-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H24ClFN4O3
Pubchem Cid	123631
Sd File	C22H24ClFN4O3 APtclcactv07281414562D 0 0.00000 0.00000 55 58 0 0 0 0 0 0 0 0999 V2000 8.9282 2.5272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9282 0.5272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5942 2.0480 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4085 -0.5274 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2687 -1.0374 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5252 -2.0173 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 1.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.5272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 1.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 3.5272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1361 -0.8112 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 1.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 2.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6882 0.4925 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5368 -1.0174 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2572 -2.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3854 -2.5273 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 1.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.5272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.9728 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -0.4728 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 2.5272 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 0.5272 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.3739 -3.5272 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -0.4728 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.1174 -2.5473 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 10.6882 2.5619 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5942 1.0064 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6766 -0.5074 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.5272 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.7942 1.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7942 2.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9282 3.1472 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9282 -0.0928 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1300 2.3601 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4157 0.0925 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8092 -0.7336 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9847 -2.3211 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8162 3.5272 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 4.1472 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5762 3.5272 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7287 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9316 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0656 0.0523 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8626 0.0523 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9966 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1995 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2646 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4675 1.5022 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7879 1.1098 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3894 0.4195 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4675 -1.4477 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2646 -1.4477 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9441 -1.0554 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3426 -0.3651 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5 16 2 0 0 0 0 12 13 2 0 0 0 0 16 17 1 0 0 0 0 3 27 2 0 0 0 0 6 17 2 0 0 0 0 6 15 1 0 0 0 0 2 31 2 0 0 0 0 17 24 1 0 0 0 0 3 28 1 0 0 0 0 16 26 1 0 0 0 0 2 12 1 0 0 0 0 13 22 1 0 0 0 0 14 28 2 0 0 0 0 10 22 1 0 0 0 0 14 31 1 0 0 0 0 12 23 1 0 0 0 0 7 23 1 0 0 0 0 14 29 1 0 0 0 0 7 8 1 0 0 0 0 1 13 1 0 0 0 0 8 9 1 0 0 0 0 15 29 1 0 0 0 0 9 30 1 0 0 0 0 18 30 1 0 0 0 0 31 32 1 0 0 0 0 4 15 2 0 0 0 0 1 32 2 0 0 0 0 4 5 1 0 0 0 0 27 32 1 0 0 0 0 21 30 1 0 0 0 0 18 19 1 0 0 0 0 19 25 1 0 0 0 0 20 25 1 0 0 0 0 20 21 1 0 0 0 0 1 33 1 0 0 0 0 2 34 1 0 0 0 0 3 35 1 0 0 0 0 11 29 1 0 0 0 0 4 36 1 0 0 0 0 5 37 1 0 0 0 0 6 38 1 0 0 0 0 10 39 1 0 0 0 0 10 40 1 0 0 0 0 10 41 1 0 0 0 0 7 42 1 0 0 0 0 7 43 1 0 0 0 0 8 44 1 0 0 0 0 8 45 1 0 0 0 0 9 46 1 0 0 0 0 9 47 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 50 1 0 0 0 0 19 51 1 0 0 0 0 20 52 1 0 0 0 0 20 53 1 0 0 0 0 21 54 1 0 0 0 0 21 55 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1=C3C(=CC(=C1OC)OCCCN2CCOCC2)C(=NC=N3)NC4=CC=C(C(=C4)Cl)F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	184475-35-2
Molecular Weight	446.9
Scientific Background	Gefitinib is a selective inhibitor of EGFR tyrosine kinase by blocking EGFR autophosphorylation.
Solubility	Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.25
Purity	>99%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Ciardiello F., et al. (2000) Clin. Cancer Res. 6(5): 2053–2063.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900229-1	SIH-445-50MG	50 mg	$73		Add to Cart
BHB11900229-2	SIH-445-250MG	250 mg	$235		Add to Cart

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