| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | APX001 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Fosmanogepix (CAS 2091769-17-2) is a research-grade small molecule supplied by TargetMol.
Alternative names: APX001
Physical Properties
| CAS Number | 2091769-17-2 |
|---|---|
| Molecular Formula | C22H21N4O6P |
| Molecular Weight | 468.40 g/mol |
| SMILES | O=P((O-))(O)OC(N+)1=CC=CC(C=2ON=C(C2)CC3=CC=C(C=C3)COC4=NC=CC=C4)=C1N |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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