Dimethyloxaloylglycine (DMOG)

Mfr.No.	SIH-382
Alternative Names	DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester
Appearance	Off-white solid
Function	Prolyl-4-hydroxylase inhibitor
Inchi	InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
Inchikey	BNJOZDZCRHCODO-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C6H9NO5
Pubchem Cid	560326
Sd File	C6H9NO5 APtclcactv07171317562D 0 0.00000 0.00000 21 20 0 0 0 0 0 0 0 0999 V2000 6.3301 -0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9282 0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.8700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 1.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 1.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -0.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 -0.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.2500 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9316 -0.7249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7287 -0.7249 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3100 0.7869 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 0.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6900 -0.2869 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2382 -0.2869 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4651 0.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6182 0.7869 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5 8 2 0 0 0 0 8 11 1 0 0 0 0 8 10 1 0 0 0 0 6 9 2 0 0 0 0 1 9 1 0 0 0 0 9 12 1 0 0 0 0 2 11 1 0 0 0 0 10 13 1 0 0 0 0 7 10 2 0 0 0 0 1 13 1 0 0 0 0 3 12 1 0 0 0 0 1 14 1 0 0 0 0 1 15 1 0 0 0 0 2 16 1 0 0 0 0 2 17 1 0 0 0 0 2 18 1 0 0 0 0 4 13 1 0 0 0 0 3 19 1 0 0 0 0 3 20 1 0 0 0 0 3 21 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling
Safety Phrases	Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes Hazard Statements: H302 - Harmful if swallowed
Smiles	C(C(=O)OC)NC(C(=O)OC)=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	89464-63-1
Molecular Weight	175.1
Scientific Background	DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
Solubility	Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>99%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Grozinger C.M., et al. (2001) J. Biol. Chem. 276(42): 38837-43. 2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95. 3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71. 4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900170-1	SIH-382-10MG	10 mg	$64		Add to Cart
BHB11900170-2	SIH-382-50MG	50 mg	$254		Add to Cart

Dimethyloxaloylglycine (DMOG)

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